4E80

Structural Basis for the Activity of a Cytoplasmic RNA Terminal U-transferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000956	biological_process	nuclear-transcribed mRNA catabolic process
A	0002134	molecular_function	UTP binding
A	0003723	molecular_function	RNA binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0036450	biological_process	polyuridylation-dependent decapping of nuclear-transcribed mRNA
A	0046872	molecular_function	metal ion binding
A	0050265	molecular_function	RNA uridylyltransferase activity
A	0060212	biological_process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
A	0061157	biological_process	mRNA destabilization
A	1990817	molecular_function	poly(A) RNA polymerase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000956	biological_process	nuclear-transcribed mRNA catabolic process
B	0002134	molecular_function	UTP binding
B	0003723	molecular_function	RNA binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0031123	biological_process	RNA 3'-end processing
B	0036450	biological_process	polyuridylation-dependent decapping of nuclear-transcribed mRNA
B	0046872	molecular_function	metal ion binding
B	0050265	molecular_function	RNA uridylyltransferase activity
B	0060212	biological_process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
B	0061157	biological_process	mRNA destabilization
B	1990817	molecular_function	poly(A) RNA polymerase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0000956	biological_process	nuclear-transcribed mRNA catabolic process
C	0002134	molecular_function	UTP binding
C	0003723	molecular_function	RNA binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0031123	biological_process	RNA 3'-end processing
C	0036450	biological_process	polyuridylation-dependent decapping of nuclear-transcribed mRNA
C	0046872	molecular_function	metal ion binding
C	0050265	molecular_function	RNA uridylyltransferase activity
C	0060212	biological_process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
C	0061157	biological_process	mRNA destabilization
C	1990817	molecular_function	poly(A) RNA polymerase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0000956	biological_process	nuclear-transcribed mRNA catabolic process
D	0002134	molecular_function	UTP binding
D	0003723	molecular_function	RNA binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0031123	biological_process	RNA 3'-end processing
D	0036450	biological_process	polyuridylation-dependent decapping of nuclear-transcribed mRNA
D	0046872	molecular_function	metal ion binding
D	0050265	molecular_function	RNA uridylyltransferase activity
D	0060212	biological_process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
D	0061157	biological_process	mRNA destabilization
D	1990817	molecular_function	poly(A) RNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UTP A 501

Chain	Residue
A	PHE88
A	SER211
A	TYR212
A	HIS336
A	GLY89
A	SER90
A	SER100
A	ALA168
A	ASN171
A	THR172
A	LYS193
A	LYS197

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UTP B 501

Chain	Residue
B	PHE88
B	GLY89
B	SER90
B	SER100
B	ALA168
B	ASN171
B	THR172
B	LYS193
B	LYS197
B	SER211
B	TYR212
B	HIS336
B	HOH601

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UTP C 501

Chain	Residue
C	PHE88
C	GLY89
C	SER90
C	SER100
C	ALA168
C	ASN171
C	THR172
C	LYS193
C	LYS197
C	SER211
C	TYR212
C	HIS336
C	HOH601

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UTP D 500

Chain	Residue
D	GLY89
D	SER90
D	ALA168
D	ASN171
D	THR172
D	LYS193
D	LYS197
D	SER211
D	TYR212
D	HIS336
D	HOH601

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22751018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4E80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22608966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24322298","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EP7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NKU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22885303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	69
Details	Domain: {"description":"PAP-associated","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---