4E5U
The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TMP A 301 |
| Chain | Residue |
| A | GLU12 |
| A | TYR104 |
| A | GLN105 |
| A | PHE155 |
| A | CA302 |
| A | HOH401 |
| A | HOH412 |
| A | HOH480 |
| A | HOH484 |
| A | HOH499 |
| A | GLU39 |
| A | PRO40 |
| A | ARG50 |
| A | MSE70 |
| A | ARG74 |
| A | ARG96 |
| A | ALA100 |
| A | THR101 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 302 |
| Chain | Residue |
| A | GLU12 |
| A | GLU156 |
| A | TMP301 |
| A | HOH483 |
| A | HOH484 |
| A | HOH499 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TMP B 301 |
| Chain | Residue |
| B | GLU12 |
| B | GLU39 |
| B | PRO40 |
| B | ARG50 |
| B | MSE70 |
| B | ARG74 |
| B | ARG96 |
| B | PHE97 |
| B | ALA100 |
| B | THR101 |
| B | TYR104 |
| B | GLN105 |
| B | PHE155 |
| B | CA302 |
| B | HOH414 |
| B | HOH426 |
| B | HOH429 |
| B | HOH437 |
| B | HOH490 |
| B | HOH500 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 302 |
| Chain | Residue |
| B | GLU12 |
| B | GLU156 |
| B | TMP301 |
| B | HOH437 |
| B | HOH500 |
| B | HOH501 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| A | ASN209 |
| B | ALA146 |
| B | ARG149 |
| B | HOH474 |
| B | HOH512 |
| B | HOH513 |
| B | HOH515 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY10 | |
| B | GLY10 |
