4E54
Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006281 | biological_process | DNA repair |
| A | 0006289 | biological_process | nucleotide-excision repair |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007056 | biological_process | spindle assembly involved in female meiosis |
| A | 0010498 | biological_process | proteasomal protein catabolic process |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0019076 | biological_process | viral release from host cell |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| A | 0031465 | cellular_component | Cul4B-RING E3 ubiquitin ligase complex |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0035234 | biological_process | ectopic germ cell programmed cell death |
| A | 0035861 | cellular_component | site of double-strand break |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0044725 | biological_process | epigenetic programming in the zygotic pronuclei |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0045732 | biological_process | positive regulation of protein catabolic process |
| A | 0046726 | biological_process | positive regulation by virus of viral protein levels in host cell |
| A | 0048511 | biological_process | rhythmic process |
| A | 0051093 | biological_process | negative regulation of developmental process |
| A | 0051702 | biological_process | biological process involved in interaction with symbiont |
| A | 0051898 | biological_process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0060337 | biological_process | type I interferon-mediated signaling pathway |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070914 | biological_process | UV-damage excision repair |
| A | 0071987 | molecular_function | WD40-repeat domain binding |
| A | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| A | 0097510 | biological_process | base-excision repair, AP site formation via deaminated base removal |
| A | 0097602 | molecular_function | cullin family protein binding |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1901990 | biological_process | regulation of mitotic cell cycle phase transition |
| A | 2000242 | biological_process | negative regulation of reproductive process |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0000785 | cellular_component | chromatin |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003684 | molecular_function | damaged DNA binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005694 | cellular_component | chromosome |
| B | 0006281 | biological_process | DNA repair |
| B | 0006289 | biological_process | nucleotide-excision repair |
| B | 0006290 | biological_process | pyrimidine dimer repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009411 | biological_process | response to UV |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030054 | cellular_component | cell junction |
| B | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| B | 0031465 | cellular_component | Cul4B-RING E3 ubiquitin ligase complex |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0034644 | biological_process | cellular response to UV |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0051865 | biological_process | protein autoubiquitination |
| B | 0070914 | biological_process | UV-damage excision repair |
| B | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| B | 0090734 | cellular_component | site of DNA damage |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAsvDqTVKIWDL |
| Chain | Residue | Details |
| B | LEU258-LEU272 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 766 |
| Details | Region: {"description":"Interaction with CDT1","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 343 |
| Details | Region: {"description":"WD repeat beta-propeller A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 316 |
| Details | Region: {"description":"WD repeat beta-propeller B; Interaction with CUL4A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 334 |
| Details | Region: {"description":"WD repeat beta-propeller C"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 369 |
| Details | Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 24 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19109893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 22 |
| Details | Region: {"description":"Required for interaction with DDB1","evidences":[{"source":"PubMed","id":"9632823","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Region: {"description":"Photolesion recognition"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | Motif: {"description":"DWD box","evidences":[{"source":"PubMed","id":"17079684","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"32789493","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
