4E4M

JAK2 kinase (JH1 domain) in complex with compound 30

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 0NH A 1201

Chain	Residue
A	LEU855
A	GLY935
A	ARG980
A	ASN981
A	LEU983
A	ASP994
A	HOH1344
B	HOH1380
A	GLY856
A	LYS857
A	GLY858
A	VAL863
A	ALA880
A	GLU930
A	TYR931
A	LEU932

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0NH B 1201

Chain	Residue
B	LEU855
B	LYS857
B	GLY858
B	ALA880
B	GLU930
B	TYR931
B	LEU932
B	GLY935
B	ARG980
B	LEU983
B	ASP994
B	HOH1415

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0NH D 1201

Chain	Residue
D	LEU855
D	LYS857
D	GLY858
D	ALA880
D	GLU930
D	TYR931
D	LEU932
D	GLY935
D	ARG980
D	ASN981
D	LEU983
D	ASP994

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 0NH E 1201

Chain	Residue
E	GLY856
E	LYS857
E	GLY858
E	VAL863
E	ALA880
E	GLU930
E	TYR931
E	LEU932
E	GLY935
E	ARG980
E	ASN981
E	LEU983
E	ASP994
E	HOH1329
E	HOH1386

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGNFGSVEmCrydplqdntgevv.....AVKK

Chain	Residue	Details
A	LEU855-LYS883

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLATRNILV

Chain	Residue	Details
A	TYR972-VAL984

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP976
B	ASP976
D	ASP976
E	ASP976

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU855
A	LYS882
B	LEU855
B	LYS882
D	LEU855
D	LYS882
E	LEU855
E	LYS882

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:Q62120

Chain	Residue	Details
A	TYR868
E	TYR868
E	TYR966
E	TYR972
A	TYR966
A	TYR972
B	TYR868
B	TYR966
B	TYR972
D	TYR868
D	TYR966
D	TYR972

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16174768

Chain	Residue	Details
A	PTR1007
B	PTR1007
D	PTR1007
E	PTR1007

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16174768

Chain	Residue	Details
A	PTR1008
B	PTR1008
D	PTR1008
E	PTR1008

---