Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4E2Q

Crystal Structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000256	biological_process	allantoin catabolic process
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006144	biological_process	purine nucleobase metabolic process
A	0006145	biological_process	purine nucleobase catabolic process
A	0006355	biological_process	regulation of DNA-templated transcription
A	0010136	biological_process	ureide catabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0071522	molecular_function	ureidoglycine aminohydrolase activity
B	0000256	biological_process	allantoin catabolic process
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0006144	biological_process	purine nucleobase metabolic process
B	0006145	biological_process	purine nucleobase catabolic process
B	0006355	biological_process	regulation of DNA-templated transcription
B	0010136	biological_process	ureide catabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0071522	molecular_function	ureidoglycine aminohydrolase activity
C	0000256	biological_process	allantoin catabolic process
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0006144	biological_process	purine nucleobase metabolic process
C	0006145	biological_process	purine nucleobase catabolic process
C	0006355	biological_process	regulation of DNA-templated transcription
C	0010136	biological_process	ureide catabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0071522	molecular_function	ureidoglycine aminohydrolase activity
D	0000256	biological_process	allantoin catabolic process
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0006144	biological_process	purine nucleobase metabolic process
D	0006145	biological_process	purine nucleobase catabolic process
D	0006355	biological_process	regulation of DNA-templated transcription
D	0010136	biological_process	ureide catabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0071522	molecular_function	ureidoglycine aminohydrolase activity
E	0000256	biological_process	allantoin catabolic process
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005829	cellular_component	cytosol
E	0006144	biological_process	purine nucleobase metabolic process
E	0006145	biological_process	purine nucleobase catabolic process
E	0006355	biological_process	regulation of DNA-templated transcription
E	0010136	biological_process	ureide catabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0071522	molecular_function	ureidoglycine aminohydrolase activity
F	0000256	biological_process	allantoin catabolic process
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0006144	biological_process	purine nucleobase metabolic process
F	0006145	biological_process	purine nucleobase catabolic process
F	0006355	biological_process	regulation of DNA-templated transcription
F	0010136	biological_process	ureide catabolic process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
F	0071522	molecular_function	ureidoglycine aminohydrolase activity
G	0000256	biological_process	allantoin catabolic process
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005783	cellular_component	endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0006144	biological_process	purine nucleobase metabolic process
G	0006145	biological_process	purine nucleobase catabolic process
G	0006355	biological_process	regulation of DNA-templated transcription
G	0010136	biological_process	ureide catabolic process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
G	0071522	molecular_function	ureidoglycine aminohydrolase activity
H	0000256	biological_process	allantoin catabolic process
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005783	cellular_component	endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0006144	biological_process	purine nucleobase metabolic process
H	0006145	biological_process	purine nucleobase catabolic process
H	0006355	biological_process	regulation of DNA-templated transcription
H	0010136	biological_process	ureide catabolic process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
H	0071522	molecular_function	ureidoglycine aminohydrolase activity
I	0000256	biological_process	allantoin catabolic process
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0005783	cellular_component	endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0006144	biological_process	purine nucleobase metabolic process
I	0006145	biological_process	purine nucleobase catabolic process
I	0006355	biological_process	regulation of DNA-templated transcription
I	0010136	biological_process	ureide catabolic process
I	0016787	molecular_function	hydrolase activity
I	0046872	molecular_function	metal ion binding
I	0071522	molecular_function	ureidoglycine aminohydrolase activity
J	0000256	biological_process	allantoin catabolic process
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0005783	cellular_component	endoplasmic reticulum
J	0005829	cellular_component	cytosol
J	0006144	biological_process	purine nucleobase metabolic process
J	0006145	biological_process	purine nucleobase catabolic process
J	0006355	biological_process	regulation of DNA-templated transcription
J	0010136	biological_process	ureide catabolic process
J	0016787	molecular_function	hydrolase activity
J	0046872	molecular_function	metal ion binding
J	0071522	molecular_function	ureidoglycine aminohydrolase activity
K	0000256	biological_process	allantoin catabolic process
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0005783	cellular_component	endoplasmic reticulum
K	0005829	cellular_component	cytosol
K	0006144	biological_process	purine nucleobase metabolic process
K	0006145	biological_process	purine nucleobase catabolic process
K	0006355	biological_process	regulation of DNA-templated transcription
K	0010136	biological_process	ureide catabolic process
K	0016787	molecular_function	hydrolase activity
K	0046872	molecular_function	metal ion binding
K	0071522	molecular_function	ureidoglycine aminohydrolase activity
L	0000256	biological_process	allantoin catabolic process
L	0003700	molecular_function	DNA-binding transcription factor activity
L	0005783	cellular_component	endoplasmic reticulum
L	0005829	cellular_component	cytosol
L	0006144	biological_process	purine nucleobase metabolic process
L	0006145	biological_process	purine nucleobase catabolic process
L	0006355	biological_process	regulation of DNA-templated transcription
L	0010136	biological_process	ureide catabolic process
L	0016787	molecular_function	hydrolase activity
L	0046872	molecular_function	metal ion binding
L	0071522	molecular_function	ureidoglycine aminohydrolase activity
M	0000256	biological_process	allantoin catabolic process
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0005783	cellular_component	endoplasmic reticulum
M	0005829	cellular_component	cytosol
M	0006144	biological_process	purine nucleobase metabolic process
M	0006145	biological_process	purine nucleobase catabolic process
M	0006355	biological_process	regulation of DNA-templated transcription
M	0010136	biological_process	ureide catabolic process
M	0016787	molecular_function	hydrolase activity
M	0046872	molecular_function	metal ion binding
M	0071522	molecular_function	ureidoglycine aminohydrolase activity
N	0000256	biological_process	allantoin catabolic process
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0005783	cellular_component	endoplasmic reticulum
N	0005829	cellular_component	cytosol
N	0006144	biological_process	purine nucleobase metabolic process
N	0006145	biological_process	purine nucleobase catabolic process
N	0006355	biological_process	regulation of DNA-templated transcription
N	0010136	biological_process	ureide catabolic process
N	0016787	molecular_function	hydrolase activity
N	0046872	molecular_function	metal ion binding
N	0071522	molecular_function	ureidoglycine aminohydrolase activity
O	0000256	biological_process	allantoin catabolic process
O	0003700	molecular_function	DNA-binding transcription factor activity
O	0005783	cellular_component	endoplasmic reticulum
O	0005829	cellular_component	cytosol
O	0006144	biological_process	purine nucleobase metabolic process
O	0006145	biological_process	purine nucleobase catabolic process
O	0006355	biological_process	regulation of DNA-templated transcription
O	0010136	biological_process	ureide catabolic process
O	0016787	molecular_function	hydrolase activity
O	0046872	molecular_function	metal ion binding
O	0071522	molecular_function	ureidoglycine aminohydrolase activity
P	0000256	biological_process	allantoin catabolic process
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0005783	cellular_component	endoplasmic reticulum
P	0005829	cellular_component	cytosol
P	0006144	biological_process	purine nucleobase metabolic process
P	0006145	biological_process	purine nucleobase catabolic process
P	0006355	biological_process	regulation of DNA-templated transcription
P	0010136	biological_process	ureide catabolic process
P	0016787	molecular_function	hydrolase activity
P	0046872	molecular_function	metal ion binding
P	0071522	molecular_function	ureidoglycine aminohydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 301

Chain	Residue
A	GLU235
A	HIS237
A	HIS241
A	GLN275
A	HOH407

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN B 301

Chain	Residue
B	GLU235
B	HIS237
B	HIS241
B	GLN275

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 301

Chain	Residue
C	GLU235
C	HIS237
C	HIS241
C	GLN275
C	HOH453

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN D 301

Chain	Residue
D	GLU235
D	HIS237
D	HIS241
D	GLN275

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 301

Chain	Residue
E	GLU235
E	HIS237
E	HIS241
E	GLN275
E	HOH435

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN F 301

Chain	Residue
F	GLU235
F	HIS237
F	HIS241
F	GLN275
F	HOH432

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 301

Chain	Residue
G	GLU235
G	HIS237
G	HIS241
G	GLN275
G	HOH430

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN H 301

Chain	Residue
H	GLU235
H	HIS237
H	HIS241
H	GLN275

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 301

Chain	Residue
I	GLU235
I	HIS237
I	HIS241
I	GLN275
I	HOH401

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 301

Chain	Residue
J	GLU235
J	HIS237
J	HIS241
J	GLN275
J	HOH434

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN K 301

Chain	Residue
K	GLU235
K	HIS237
K	HIS241
K	GLN275

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN L 301

Chain	Residue
L	GLU235
L	HIS237
L	HIS241
L	GLN275
L	HOH424

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN M 301

Chain	Residue
M	GLU235
M	HIS237
M	HIS241
M	GLN275

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN N 301

Chain	Residue
N	GLU235
N	HIS237
N	HIS241
N	GLN275
N	HOH409
N	HOH442

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN O 301

Chain	Residue
O	GLU235
O	HIS237
O	HIS241
O	GLN275
O	HOH401

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN P 301

Chain	Residue
P	GLU235
P	HIS237
P	HIS241
P	GLN275
P	HOH409

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	BINDING: BINDING => ECO:0000269\|PubMed:22493446

Chain	Residue	Details
A	GLU235
B	GLN275
B	TYR287
B	LYS291
C	GLU235
C	HIS237
C	HIS241
C	GLN275
C	TYR287
C	LYS291
D	GLU235
A	HIS237
D	HIS237
D	HIS241
D	GLN275
D	TYR287
D	LYS291
E	GLU235
E	HIS237
E	HIS241
E	GLN275
E	TYR287
A	HIS241
E	LYS291
F	GLU235
F	HIS237
F	HIS241
F	GLN275
F	TYR287
F	LYS291
G	GLU235
G	HIS237
G	HIS241
A	GLN275
G	GLN275
G	TYR287
G	LYS291
H	GLU235
H	HIS237
H	HIS241
H	GLN275
H	TYR287
H	LYS291
I	GLU235
A	TYR287
I	HIS237
I	HIS241
I	GLN275
I	TYR287
I	LYS291
J	GLU235
J	HIS237
J	HIS241
J	GLN275
J	TYR287
A	LYS291
J	LYS291
K	GLU235
K	HIS237
K	HIS241
K	GLN275
K	TYR287
K	LYS291
L	GLU235
L	HIS237
L	HIS241
B	GLU235
L	GLN275
L	TYR287
L	LYS291
M	GLU235
M	HIS237
M	HIS241
M	GLN275
M	TYR287
M	LYS291
N	GLU235
B	HIS237
N	HIS237
N	HIS241
N	GLN275
N	TYR287
N	LYS291
O	GLU235
O	HIS237
O	HIS241
O	GLN275
O	TYR287
B	HIS241
O	LYS291
P	GLU235
P	HIS237
P	HIS241
P	GLN275
P	TYR287
P	LYS291

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)