Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4E1V

X-RAY Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with 5-Fluorouracil at 2.15 A Resolution

Replaces: 3NSR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage
G	0003824	molecular_function	catalytic activity
G	0004850	molecular_function	uridine phosphorylase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009116	biological_process	nucleoside metabolic process
G	0009164	biological_process	nucleoside catabolic process
G	0009166	biological_process	nucleotide catabolic process
G	0016757	molecular_function	glycosyltransferase activity
G	0016763	molecular_function	pentosyltransferase activity
G	0044206	biological_process	UMP salvage
H	0003824	molecular_function	catalytic activity
H	0004850	molecular_function	uridine phosphorylase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009116	biological_process	nucleoside metabolic process
H	0009164	biological_process	nucleoside catabolic process
H	0009166	biological_process	nucleotide catabolic process
H	0016757	molecular_function	glycosyltransferase activity
H	0016763	molecular_function	pentosyltransferase activity
H	0044206	biological_process	UMP salvage
I	0003824	molecular_function	catalytic activity
I	0004850	molecular_function	uridine phosphorylase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009116	biological_process	nucleoside metabolic process
I	0009164	biological_process	nucleoside catabolic process
I	0009166	biological_process	nucleotide catabolic process
I	0016757	molecular_function	glycosyltransferase activity
I	0016763	molecular_function	pentosyltransferase activity
I	0044206	biological_process	UMP salvage

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URF A 1301

Chain	Residue
A	THR1095
A	GOL1302
A	HOH1410
A	GLY1096
A	PHE1162
A	GLN1166
A	ARG1168
A	GLU1196
A	MET1197
A	ILE1220
A	VAL1221

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1302

Chain	Residue
A	THR1094
A	GLU1196
A	MET1197
A	GLU1198
A	URF1301
A	HOH1454

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 1303

Chain	Residue
A	GLU1049
A	ILE1069
A	SER1073
B	GLU1049
B	ILE1069
B	SER1073

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE URF E 1301

Chain	Residue
E	THR1094
E	THR1095
E	GLY1096
E	PHE1162
E	GLN1166
E	ARG1168
E	GLU1196
E	MET1197
E	ILE1220
E	VAL1221
E	PRO1229
E	GOL1302
E	HOH1411

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 1302

Chain	Residue
E	THR1094
E	GLU1196
E	MET1197
E	GLU1198
E	URF1301
E	HOH1456

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 1303

Chain	Residue
E	GLU1049
E	ILE1069
E	SER1073
F	GLU1049
F	ILE1069
F	SER1073

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URF F 1301

Chain	Residue
F	THR1095
F	GLY1096
F	GLN1166
F	ARG1168
F	TYR1195
F	GLU1196
F	MET1197
F	ILE1220
F	VAL1221
F	GOL1302
F	HOH1409

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL F 1302

Chain	Residue
F	THR1094
F	GLU1196
F	MET1197
F	GLU1198
F	URF1301
F	HOH1461

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URF D 1301

Chain	Residue
D	THR1095
D	GLY1096
D	PHE1162
D	GLN1166
D	ARG1168
D	GLU1196
D	MET1197
D	ILE1220
D	VAL1221
D	HOH1447

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 1302

Chain	Residue
C	GLU1049
C	ILE1069
C	SER1073
D	GLU1049
D	ILE1069
D	SER1073

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URF C 1301

Chain	Residue
C	THR1095
C	GLY1096
C	PHE1162
C	GLN1166
C	ARG1168
C	GLU1196
C	MET1197
C	ILE1220
C	VAL1221
C	GOL1303
C	HOH1414

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 1302

Chain	Residue
C	ARG1179
C	HOH1409
C	HOH1425
D	LEU1121

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 1303

Chain	Residue
C	GLU1198
C	URF1301
C	HOH1448
D	HIS1008
C	THR1094
C	GLU1196
C	MET1197

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE URF B 1301

Chain	Residue
B	THR1095
B	GLY1096
B	GLN1166
B	ARG1168
B	TYR1195
B	GLU1196
B	MET1197
B	ILE1220
B	VAL1221
B	PRO1229
B	GOL1302
B	HOH1415

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1302

Chain	Residue
B	THR1094
B	GLU1196
B	MET1197
B	GLU1198
B	URF1301

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE URF H 1301

Chain	Residue
H	THR1094
H	THR1095
H	GLY1096
H	PHE1162
H	GLN1166
H	ARG1168
H	GLU1196
H	MET1197
H	ILE1220
H	VAL1221

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URF G 1301

Chain	Residue
G	THR1095
G	GLY1096
G	PHE1162
G	GLN1166
G	ARG1168
G	MET1197
G	ILE1220
G	VAL1221
G	PRO1229

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER1066-LEU1081

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)