4E1V
X-RAY Structure of the Uridine Phosphorylase from Salmonella Typhimurium in Complex with 5-Fluorouracil at 2.15 A Resolution
Replaces: 3NSRFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004850 | molecular_function | uridine phosphorylase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0009116 | biological_process | nucleoside metabolic process |
| G | 0009166 | biological_process | nucleotide catabolic process |
| G | 0016763 | molecular_function | pentosyltransferase activity |
| G | 0044206 | biological_process | UMP salvage |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004850 | molecular_function | uridine phosphorylase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0009116 | biological_process | nucleoside metabolic process |
| H | 0009166 | biological_process | nucleotide catabolic process |
| H | 0016763 | molecular_function | pentosyltransferase activity |
| H | 0044206 | biological_process | UMP salvage |
| I | 0003824 | molecular_function | catalytic activity |
| I | 0004850 | molecular_function | uridine phosphorylase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0009116 | biological_process | nucleoside metabolic process |
| I | 0009166 | biological_process | nucleotide catabolic process |
| I | 0016763 | molecular_function | pentosyltransferase activity |
| I | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE URF A 1301 |
| Chain | Residue |
| A | THR1095 |
| A | GOL1302 |
| A | HOH1410 |
| A | GLY1096 |
| A | PHE1162 |
| A | GLN1166 |
| A | ARG1168 |
| A | GLU1196 |
| A | MET1197 |
| A | ILE1220 |
| A | VAL1221 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1302 |
| Chain | Residue |
| A | THR1094 |
| A | GLU1196 |
| A | MET1197 |
| A | GLU1198 |
| A | URF1301 |
| A | HOH1454 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1303 |
| Chain | Residue |
| A | GLU1049 |
| A | ILE1069 |
| A | SER1073 |
| B | GLU1049 |
| B | ILE1069 |
| B | SER1073 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE URF E 1301 |
| Chain | Residue |
| E | THR1094 |
| E | THR1095 |
| E | GLY1096 |
| E | PHE1162 |
| E | GLN1166 |
| E | ARG1168 |
| E | GLU1196 |
| E | MET1197 |
| E | ILE1220 |
| E | VAL1221 |
| E | PRO1229 |
| E | GOL1302 |
| E | HOH1411 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 1302 |
| Chain | Residue |
| E | THR1094 |
| E | GLU1196 |
| E | MET1197 |
| E | GLU1198 |
| E | URF1301 |
| E | HOH1456 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 1303 |
| Chain | Residue |
| E | GLU1049 |
| E | ILE1069 |
| E | SER1073 |
| F | GLU1049 |
| F | ILE1069 |
| F | SER1073 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE URF F 1301 |
| Chain | Residue |
| F | THR1095 |
| F | GLY1096 |
| F | GLN1166 |
| F | ARG1168 |
| F | TYR1195 |
| F | GLU1196 |
| F | MET1197 |
| F | ILE1220 |
| F | VAL1221 |
| F | GOL1302 |
| F | HOH1409 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL F 1302 |
| Chain | Residue |
| F | THR1094 |
| F | GLU1196 |
| F | MET1197 |
| F | GLU1198 |
| F | URF1301 |
| F | HOH1461 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE URF D 1301 |
| Chain | Residue |
| D | THR1095 |
| D | GLY1096 |
| D | PHE1162 |
| D | GLN1166 |
| D | ARG1168 |
| D | GLU1196 |
| D | MET1197 |
| D | ILE1220 |
| D | VAL1221 |
| D | HOH1447 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 1302 |
| Chain | Residue |
| C | GLU1049 |
| C | ILE1069 |
| C | SER1073 |
| D | GLU1049 |
| D | ILE1069 |
| D | SER1073 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE URF C 1301 |
| Chain | Residue |
| C | THR1095 |
| C | GLY1096 |
| C | PHE1162 |
| C | GLN1166 |
| C | ARG1168 |
| C | GLU1196 |
| C | MET1197 |
| C | ILE1220 |
| C | VAL1221 |
| C | GOL1303 |
| C | HOH1414 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 1302 |
| Chain | Residue |
| C | ARG1179 |
| C | HOH1409 |
| C | HOH1425 |
| D | LEU1121 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1303 |
| Chain | Residue |
| C | GLU1198 |
| C | URF1301 |
| C | HOH1448 |
| D | HIS1008 |
| C | THR1094 |
| C | GLU1196 |
| C | MET1197 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE URF B 1301 |
| Chain | Residue |
| B | THR1095 |
| B | GLY1096 |
| B | GLN1166 |
| B | ARG1168 |
| B | TYR1195 |
| B | GLU1196 |
| B | MET1197 |
| B | ILE1220 |
| B | VAL1221 |
| B | PRO1229 |
| B | GOL1302 |
| B | HOH1415 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1302 |
| Chain | Residue |
| B | THR1094 |
| B | GLU1196 |
| B | MET1197 |
| B | GLU1198 |
| B | URF1301 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE URF H 1301 |
| Chain | Residue |
| H | THR1094 |
| H | THR1095 |
| H | GLY1096 |
| H | PHE1162 |
| H | GLN1166 |
| H | ARG1168 |
| H | GLU1196 |
| H | MET1197 |
| H | ILE1220 |
| H | VAL1221 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE URF G 1301 |
| Chain | Residue |
| G | THR1095 |
| G | GLY1096 |
| G | PHE1162 |
| G | GLN1166 |
| G | ARG1168 |
| G | MET1197 |
| G | ILE1220 |
| G | VAL1221 |
| G | PRO1229 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER1066-LEU1081 |
