4E1S

X-ray crystal structure of the transmembrane beta-domain from intimin from EHEC strain O157:H7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	ARG333
A	ASN335

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLC A 502

Chain	Residue
A	ILE389
A	OLC505
A	OLC514
A	GLN218
A	SER219
A	GLY225
A	SER226
A	TYR250
A	VAL377
A	TYR379

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OLC A 503

Chain	Residue
A	GLY273
A	GLY292
A	GLY293
A	VAL304
A	ARG309
A	ASN328
A	TYR354
A	OLC509
A	HOH727

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLB A 504

Chain	Residue
A	TYR235
A	GLN263
A	TYR274
A	OLC506
A	OLC509
A	OLC511
A	OLC513

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OLC A 505

Chain	Residue
A	VAL215
A	SER226
A	ALA248
A	TYR379
A	MET387
A	OLC502
A	OLB508
A	OLC512
A	OLC514

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OLC A 506

Chain	Residue
A	PHE234
A	TYR235
A	LEU338
A	PRO339
A	SER340
A	OLB504
A	OLC511
A	OLC513

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLC A 507

Chain	Residue
A	ARG297
A	ASP298
A	TYR299
A	TYR337
A	LEU338
A	LEU344
A	ALA346
A	VAL377
A	OLC512
A	HOH753

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLB A 508

Chain	Residue
A	SER219
A	GLY220
A	ASN221
A	TYR403
A	TYR409
A	OLC505
A	HOH759

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLC A 509

Chain	Residue
A	ARG309
A	MET310
A	GLY312
A	TRP313
A	ARG325
A	PHE330
A	TYR354
A	OLC503
A	OLB504
A	OLB510

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLB A 510

Chain	Residue
A	VAL304
A	PHE330
A	ILE332
A	GLN352
A	TYR354
A	ASN369
A	OLC509

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE OLC A 511

Chain	Residue
A	LEU232
A	PRO233
A	PHE234
A	GLY244
A	ALA261
A	ILE278
A	SER340
A	TYR341
A	LEU344
A	OLB504
A	OLC506
A	HOH698

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLC A 512

Chain	Residue
A	TYR341
A	VAL377
A	OLC505
A	OLC507
A	OLC514

---

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLC A 513

Chain	Residue
A	GLN263
A	LEU267
A	LEU272
A	TYR274
A	OLB504
A	OLC506
A	HOH730
A	TYR235
A	SER237
A	MET240

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLC A 514

Chain	Residue
A	HIS209
A	PHE230
A	ALA257
A	OLC502
A	OLC505
A	OLC512
A	HOH759

---

Functional Information from PROSITE/UniProt

site_id	PS00180
Number of Residues	19
Details	GLNA_1 Glutamine synthetase signature 1. FDGSSldfllpfyDSEkmL

Chain	Residue	Details
A	PHE223-LEU241

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	201
Details	Region: {"description":"Inverse autotransporter","evidences":[{"source":"PubMed","id":"22658748","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"Signature sequence for beta-barrel assembly machinery (BAM), which recognizes the unfolded beta-barrel in the periplasm","evidences":[{"source":"PubMed","id":"22658748","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Minimum linker residues necessary for formation of a heat-modifiable beta-barrel","evidences":[{"source":"PubMed","id":"22658748","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---