4E1L
Crystal structure of Acetoacetyl-CoA thiolase (thlA2) from Clostridium difficile
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 401 |
| Chain | Residue |
| A | GLY383 |
| C | ASN64 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 402 |
| Chain | Residue |
| A | ASN64 |
| A | THR83 |
| C | LYS86 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 403 |
| Chain | Residue |
| A | ASN317 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 404 |
| Chain | Residue |
| A | LYS216 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 405 |
| Chain | Residue |
| A | ASN44 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 406 |
| Chain | Residue |
| A | GLN263 |
| A | ASP3 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 407 |
| Chain | Residue |
| A | LYS328 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 408 |
| Chain | Residue |
| A | LYS86 |
| C | ASN85 |
| C | LYS86 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 409 |
| Chain | Residue |
| A | THR160 |
| A | HOH516 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 411 |
| Chain | Residue |
| A | PHE226 |
| A | IOD412 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 412 |
| Chain | Residue |
| A | LEU180 |
| A | ASN184 |
| A | IOD411 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 402 |
| Chain | Residue |
| B | LYS133 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 403 |
| Chain | Residue |
| B | ASN317 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 404 |
| Chain | Residue |
| B | GLY383 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 405 |
| Chain | Residue |
| B | LYS216 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 406 |
| Chain | Residue |
| B | ASN72 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 408 |
| Chain | Residue |
| B | GLN263 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 411 |
| Chain | Residue |
| B | GLN367 |
| B | LYS368 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 412 |
| Chain | Residue |
| B | SER335 |
| B | SER336 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 413 |
| Chain | Residue |
| B | THR160 |
| B | HOH515 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 401 |
| Chain | Residue |
| C | ASP3 |
| C | GLN263 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 402 |
| Chain | Residue |
| C | LYS216 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 403 |
| Chain | Residue |
| A | ASN64 |
| C | GLY381 |
| C | GLY383 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 404 |
| Chain | Residue |
| C | ASN317 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 405 |
| Chain | Residue |
| C | VAL27 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 408 |
| Chain | Residue |
| C | ASN72 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 414 |
| Chain | Residue |
| C | GLU197 |
| C | GLN367 |
| C | LYS368 |
| site_id | DC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 415 |
| Chain | Residue |
| C | MET224 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 401 |
| Chain | Residue |
| D | ASP3 |
| D | GLN263 |
| site_id | DC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 403 |
| Chain | Residue |
| D | ASN317 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 404 |
| Chain | Residue |
| B | ASN64 |
| D | GLY383 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 405 |
| Chain | Residue |
| B | ASN85 |
| D | LYS86 |
| site_id | DC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 406 |
| Chain | Residue |
| D | ASN72 |
| site_id | DC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 407 |
| Chain | Residue |
| D | VAL27 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD D 408 |
| Chain | Residue |
| B | ASN64 |
| B | THR83 |
| D | LYS86 |
| D | LEU87 |
| site_id | DC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 411 |
| Chain | Residue |
| D | GLN63 |
| site_id | EC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 413 |
| Chain | Residue |
| D | SER119 |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNKlCGSGLkSVqlaaqsI |
| Chain | Residue | Details |
| A | VAL84-ILE102 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GLATLCIGgGqGiS |
| Chain | Residue | Details |
| A | GLY374-SER387 |
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPiGaSG |
| Chain | Residue | Details |
| A | ASN339-GLY355 |
