4E0N
SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II)
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 101 |
| Chain | Residue |
| A | ORN0 |
| A | HOH208 |
| D | LYS7 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD A 102 |
| Chain | Residue |
| A | PHE10 |
| A | HAO11 |
| A | 4BF12 |
| A | HOH203 |
| B | 4BF12 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 101 |
| Chain | Residue |
| A | ORN8 |
| A | HOH213 |
| B | TYR6 |
| B | ORN8 |
| B | HOH201 |
| B | HOH204 |
| B | HOH209 |
| D | PO4102 |
| D | HOH207 |
| A | TYR6 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD B 102 |
| Chain | Residue |
| A | 4BF12 |
| B | GLN3 |
| B | HAO11 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD C 101 |
| Chain | Residue |
| C | TYR6 |
| C | PHE10 |
| C | 4BF12 |
| C | HOH204 |
| D | VAL2 |
| D | 4BF12 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MPD C 102 |
| Chain | Residue |
| C | PHE10 |
| C | HAO11 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 D 101 |
| Chain | Residue |
| C | TYR6 |
| C | ORN8 |
| D | TYR6 |
| D | ORN8 |
| D | PO4102 |
| D | HOH202 |
| D | HOH209 |
| D | HOH211 |
| D | HOH212 |
| D | HOH216 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 D 102 |
| Chain | Residue |
| A | HOH204 |
| B | ORN8 |
| B | PO4101 |
| C | HOH203 |
| D | ORN8 |
| D | PO4101 |
| D | HOH203 |
| D | HOH204 |
| D | HOH207 |
| D | HOH212 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD D 103 |
| Chain | Residue |
| D | GLU9 |
| D | PHE10 |
| D | HAO11 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
