4E0I

Crystal structure of the C30S/C133S mutant of Erv1 from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006879	biological_process	intracellular iron ion homeostasis
A	0015035	molecular_function	protein-disulfide reductase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
A	0016972	molecular_function	thiol oxidase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0045041	biological_process	protein import into mitochondrial intermembrane space
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0160203	biological_process	mitochondrial disulfide relay system
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006879	biological_process	intracellular iron ion homeostasis
B	0015035	molecular_function	protein-disulfide reductase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
B	0016972	molecular_function	thiol oxidase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0045041	biological_process	protein import into mitochondrial intermembrane space
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0160203	biological_process	mitochondrial disulfide relay system
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0006879	biological_process	intracellular iron ion homeostasis
C	0015035	molecular_function	protein-disulfide reductase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016971	molecular_function	flavin-dependent sulfhydryl oxidase activity
C	0016972	molecular_function	thiol oxidase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0045041	biological_process	protein import into mitochondrial intermembrane space
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0160203	biological_process	mitochondrial disulfide relay system

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FAD A 201

Chain	Residue
A	GLU88
A	HIS162
A	ASN163
A	VAL165
A	ASN166
A	LYS168
A	LEU169
A	LYS171
A	PHE174
A	ARG182
A	TRP183
A	GLY91
B	TYR79
C	GLU88
A	ARG92
A	SER94
A	TRP95
A	HIS99
A	TYR128
A	SER133
A	CYS159

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE FAD B 201

Chain	Residue
B	VAL87
B	GLY91
B	ARG92
B	TRP95
B	HIS99
B	TYR128
B	TRP132
B	SER133
B	CYS159
B	HIS162
B	ASN163
B	VAL165
B	ASN166
B	LYS168
B	LEU169
B	LYS171
B	PHE174
B	ARG182
B	TRP183

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FAD C 201

Chain	Residue
A	GLU88
C	TYR79
C	GLU88
C	GLY91
C	ARG92
C	SER94
C	TRP95
C	HIS99
C	TYR128
C	TRP132
C	SER133
C	PHE137
C	CYS159
C	HIS162
C	ASN163
C	VAL165
C	ASN166
C	LYS168
C	LEU169
C	LYS171
C	PHE174
C	ARG182
C	TRP183

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"ERV/ALR sulfhydryl oxidase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00654","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	66
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P55789","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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