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4DZW

Crystal Structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(cyclohexylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0004161molecular_functiondimethylallyltranstransferase activity
A0004337molecular_function(2E,6E)-farnesyl diphosphate synthase activity
A0004659molecular_functionprenyltransferase activity
A0005737cellular_componentcytoplasm
A0008299biological_processisoprenoid biosynthetic process
A0016740molecular_functiontransferase activity
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
A0045337biological_processfarnesyl diphosphate biosynthetic process
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 0MQ A 401
ChainResidue
AASP98
AMG402
AMG403
AIPE404
AARG107
AGLN167
ALYS207
ATYR211
AGLN247
AASP250
ALYS264
ALYS273

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 402
ChainResidue
AASP98
AASP102
A0MQ401

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 403
ChainResidue
AASP250
AASP268
A0MQ401

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE IPE A 404
ChainResidue
AGLY47
ALYS48
ATYR49
APHE50
AARG51
AGLN91
ALEU95
AARG108
ATYR211
A0MQ401

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 A 405
ChainResidue
AHIS141

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 406
ChainResidue
AVAL96
AASP99
AARG107
ACYS112
ATRP113

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. IGeyFQVqDDVmD
ChainResidueDetails
AILE242-ASP254

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVeDDim..DgsvmRRG
ChainResidueDetails
ALEU95-GLY109

246704

PDB entries from 2025-12-24

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