4DZ4
X-ray crystal structure of a hypothetical Agmatinase from Burkholderia thailandensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008783 | molecular_function | agmatinase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| A | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008783 | molecular_function | agmatinase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| B | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008783 | molecular_function | agmatinase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| C | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008783 | molecular_function | agmatinase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| D | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0008783 | molecular_function | agmatinase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| E | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0008783 | molecular_function | agmatinase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016813 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines |
| F | 0033389 | biological_process | putrescine biosynthetic process from arginine, using agmatinase |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | ASP159 |
| A | HIS161 |
| A | ASP242 |
| A | ASP244 |
| A | MN402 |
| A | HOH739 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 402 |
| Chain | Residue |
| A | ASP242 |
| A | MN401 |
| A | HOH739 |
| A | HIS135 |
| A | ASP159 |
| A | ASP163 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 403 |
| Chain | Residue |
| A | ARG59 |
| A | SER60 |
| A | TYR291 |
| A | HOH518 |
| A | HOH575 |
| C | ASP53 |
| C | GLY61 |
| C | ARG63 |
| C | LEU64 |
| C | ALA290 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 404 |
| Chain | Residue |
| A | GLU295 |
| A | HOH525 |
| A | HOH787 |
| B | LEU64 |
| D | PHE58 |
| D | ARG59 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 405 |
| Chain | Residue |
| A | LEU64 |
| A | SER67 |
| A | ALA68 |
| A | HOH524 |
| A | HOH607 |
| A | HOH775 |
| B | HOH602 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 406 |
| Chain | Residue |
| A | SER19 |
| A | LEU79 |
| A | ASN80 |
| A | ASP87 |
| A | HOH627 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | HIS135 |
| B | ASP159 |
| B | ASP163 |
| B | ASP242 |
| B | MN402 |
| B | HOH752 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 402 |
| Chain | Residue |
| B | ASP159 |
| B | HIS161 |
| B | ASP242 |
| B | ASP244 |
| B | MN401 |
| B | HOH752 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 403 |
| Chain | Residue |
| B | TRP165 |
| B | TRP201 |
| B | ASN202 |
| B | ASP203 |
| B | HOH613 |
| E | ASN80 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 404 |
| Chain | Residue |
| B | GLU78 |
| B | HOH808 |
| C | THR57 |
| C | TRP165 |
| C | THR256 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 405 |
| Chain | Residue |
| B | SER19 |
| B | ALA77 |
| B | GLU78 |
| B | LEU79 |
| B | ASN80 |
| B | ASP87 |
| B | HOH670 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 406 |
| Chain | Residue |
| B | THR57 |
| B | HIS175 |
| B | THR256 |
| B | HOH807 |
| E | GLU78 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 407 |
| Chain | Residue |
| A | LEU64 |
| B | GLU295 |
| B | HOH513 |
| B | HOH617 |
| C | ARG59 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 408 |
| Chain | Residue |
| B | ARG59 |
| B | SER60 |
| B | TYR291 |
| B | HOH525 |
| D | GLY61 |
| D | ARG63 |
| D | LEU64 |
| D | ALA290 |
| D | HOH598 |
| site_id | BC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 409 |
| Chain | Residue |
| B | PRO107 |
| B | LEU108 |
| B | ILE110 |
| B | LYS111 |
| B | TYR136 |
| B | ASP171 |
| B | LEU173 |
| B | HOH592 |
| B | HOH756 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 410 |
| Chain | Residue |
| B | GLU22 |
| B | THR24 |
| B | ALA77 |
| B | GLU78 |
| B | HOH545 |
| B | HOH647 |
| B | HOH695 |
| B | SER20 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 411 |
| Chain | Residue |
| A | ILE11 |
| B | THR37 |
| B | ARG38 |
| B | ASP39 |
| B | HOH584 |
| B | HOH709 |
| B | HOH802 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 412 |
| Chain | Residue |
| B | GLU295 |
| B | HOH519 |
| B | HOH590 |
| B | HOH602 |
| B | HOH609 |
| B | HOH668 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 401 |
| Chain | Residue |
| C | ASP159 |
| C | HIS161 |
| C | ASP242 |
| C | ASP244 |
| C | MN402 |
| C | HOH711 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 402 |
| Chain | Residue |
| C | HIS135 |
| C | ASP159 |
| C | ASP163 |
| C | ASP242 |
| C | MN401 |
| C | HOH711 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 403 |
| Chain | Residue |
| C | GLU78 |
| C | LEU79 |
| C | ASN80 |
| C | ASP87 |
| C | HOH604 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 404 |
| Chain | Residue |
| B | ASN80 |
| C | TRP201 |
| C | ASN202 |
| C | ASP203 |
| C | HOH654 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO C 405 |
| Chain | Residue |
| A | GLY61 |
| A | ARG63 |
| A | LEU64 |
| A | ALA290 |
| A | HOH575 |
| C | ARG59 |
| C | SER60 |
| C | TYR291 |
| C | HOH503 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 406 |
| Chain | Residue |
| C | ARG127 |
| C | TRP312 |
| C | LYS316 |
| C | HOH733 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 407 |
| Chain | Residue |
| C | LEU64 |
| C | SER67 |
| C | ALA68 |
| C | HOH573 |
| C | HOH597 |
| C | HOH613 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 408 |
| Chain | Residue |
| C | GLU295 |
| C | HOH588 |
| C | HOH635 |
| E | ARG59 |
| F | LEU64 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 409 |
| Chain | Residue |
| C | PRO107 |
| C | LEU108 |
| C | ILE110 |
| C | LYS111 |
| C | TYR136 |
| C | ASP171 |
| C | LEU173 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 410 |
| Chain | Residue |
| B | ALA221 |
| B | GLN266 |
| B | HOH763 |
| C | HIS217 |
| C | HOH526 |
| C | HOH578 |
| C | HOH637 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 401 |
| Chain | Residue |
| D | ASP159 |
| D | HIS161 |
| D | ASP242 |
| D | ASP244 |
| D | MN402 |
| D | HOH793 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 402 |
| Chain | Residue |
| D | HIS135 |
| D | ASP159 |
| D | ASP163 |
| D | ASP242 |
| D | MN401 |
| D | HOH793 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 403 |
| Chain | Residue |
| D | ARG127 |
| D | TRP312 |
| D | ARG315 |
| D | HOH744 |
| D | HOH766 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO D 404 |
| Chain | Residue |
| D | GLY18 |
| D | ASP90 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 405 |
| Chain | Residue |
| D | SER19 |
| D | ALA77 |
| D | LEU79 |
| D | ASN80 |
| D | ASP87 |
| D | HOH602 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 406 |
| Chain | Residue |
| D | GLU78 |
| D | HOH704 |
| D | HOH794 |
| F | TRP165 |
| F | HOH694 |
| site_id | DC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO D 407 |
| Chain | Residue |
| B | GLY61 |
| B | ARG63 |
| B | LEU64 |
| B | ALA290 |
| D | ARG59 |
| D | SER60 |
| D | TYR291 |
| D | HOH510 |
| D | HOH598 |
| site_id | DC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO D 408 |
| Chain | Residue |
| D | LEU64 |
| D | SER67 |
| D | ALA68 |
| D | HOH511 |
| D | HOH618 |
| D | HOH654 |
| D | HOH692 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 409 |
| Chain | Residue |
| D | GLU295 |
| D | HOH568 |
| D | HOH620 |
| E | LEU64 |
| F | PHE58 |
| F | ARG59 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 410 |
| Chain | Residue |
| A | ASN80 |
| D | TRP201 |
| D | ASN202 |
| D | ASP203 |
| D | HOH786 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 401 |
| Chain | Residue |
| E | HIS135 |
| E | ASP159 |
| E | ASP163 |
| E | ASP242 |
| E | MN402 |
| E | HOH775 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN E 402 |
| Chain | Residue |
| E | ASP159 |
| E | HIS161 |
| E | ASP242 |
| E | ASP244 |
| E | MN401 |
| E | HOH775 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 403 |
| Chain | Residue |
| E | ARG127 |
| E | ARG315 |
| E | LYS316 |
| E | HOH710 |
| E | HOH822 |
| site_id | EC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 404 |
| Chain | Residue |
| E | GLU78 |
| E | LEU79 |
| E | ASN80 |
| E | ASP87 |
| E | HOH641 |
| E | HOH769 |
| site_id | EC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 405 |
| Chain | Residue |
| C | ASN80 |
| E | TRP201 |
| E | ASN202 |
| E | ASP203 |
| E | HOH689 |
| site_id | EC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 406 |
| Chain | Residue |
| E | TYR82 |
| E | HOH823 |
| E | HOH826 |
| site_id | EC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO E 407 |
| Chain | Residue |
| E | ARG59 |
| E | SER60 |
| E | TYR291 |
| E | HOH513 |
| E | HOH628 |
| F | GLY61 |
| F | ARG63 |
| F | LEU64 |
| F | ALA290 |
| site_id | FC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO E 408 |
| Chain | Residue |
| E | LEU64 |
| E | SER67 |
| E | ALA68 |
| E | PRO289 |
| E | HOH524 |
| E | HOH631 |
| E | HOH634 |
| E | HOH701 |
| site_id | FC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO E 409 |
| Chain | Residue |
| B | PHE58 |
| B | ARG59 |
| D | LEU64 |
| E | GLU295 |
| E | HOH609 |
| E | HOH640 |
| site_id | FC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 410 |
| Chain | Residue |
| C | GLU78 |
| E | THR57 |
| E | HIS175 |
| E | THR256 |
| E | HOH819 |
| site_id | FC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO E 411 |
| Chain | Residue |
| B | HIS217 |
| E | ALA221 |
| E | GLN266 |
| E | ALA269 |
| E | HOH559 |
| E | HOH663 |
| E | HOH669 |
| E | HOH739 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN F 401 |
| Chain | Residue |
| F | ASP159 |
| F | HIS161 |
| F | ASP242 |
| F | ASP244 |
| F | MN402 |
| F | HOH738 |
| site_id | FC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN F 402 |
| Chain | Residue |
| F | HIS135 |
| F | ASP159 |
| F | ASP163 |
| F | ASP242 |
| F | MN401 |
| F | HOH738 |
| site_id | FC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 403 |
| Chain | Residue |
| D | ASN80 |
| F | TRP165 |
| F | TRP201 |
| F | ASN202 |
| F | ASP203 |
| F | HOH705 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO F 404 |
| Chain | Residue |
| F | TRP215 |
| F | HIS219 |
| F | ARG227 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO F 405 |
| Chain | Residue |
| F | PRO83 |
| F | TRP84 |
| F | ARG272 |
| site_id | GC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO F 406 |
| Chain | Residue |
| F | ARG127 |
| F | TRP312 |
| F | LYS316 |
| F | HOH698 |
| site_id | GC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO F 407 |
| Chain | Residue |
| F | LEU64 |
| F | SER67 |
| F | ALA68 |
| F | PRO289 |
| F | HOH607 |
| F | HOH611 |
| F | HOH641 |
| F | HOH642 |
| site_id | GC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO F 408 |
| Chain | Residue |
| E | GLY61 |
| E | ARG63 |
| E | LEU64 |
| E | ALA290 |
| E | HOH628 |
| F | ARG59 |
| F | SER60 |
| F | TYR291 |
| F | HOH510 |
| site_id | GC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO F 409 |
| Chain | Residue |
| A | HIS217 |
| A | HOH617 |
| F | ALA221 |
| F | GLN266 |
| F | ALA269 |
| F | HOH569 |
| F | HOH636 |
| site_id | GC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO F 410 |
| Chain | Residue |
| A | PHE58 |
| A | ARG59 |
| C | LEU64 |
| F | GLU295 |
| F | HOH572 |
| F | HOH763 |
Functional Information from PROSITE/UniProt
| site_id | PS01053 |
| Number of Residues | 22 |
| Details | ARGINASE_1 Arginase family signature. TFDIDcldPafaPGtgtpvagG |
| Chain | Residue | Details |
| A | THR240-GLY261 |
