4DY0

Crystal structure of native protease nexin-1 with heparin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005539	molecular_function	glycosaminoglycan binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0007399	biological_process	nervous system development
A	0008201	molecular_function	heparin binding
A	0010544	biological_process	negative regulation of platelet activation
A	0010757	biological_process	negative regulation of plasminogen activation
A	0010955	biological_process	negative regulation of protein processing
A	0030154	biological_process	cell differentiation
A	0030195	biological_process	negative regulation of blood coagulation
A	0030334	biological_process	regulation of cell migration
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0031091	cellular_component	platelet alpha granule
A	0031594	cellular_component	neuromuscular junction
A	0045861	biological_process	negative regulation of proteolysis
A	0048711	biological_process	positive regulation of astrocyte differentiation
A	0090331	biological_process	negative regulation of platelet aggregation
A	1903561	cellular_component	extracellular vesicle
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005539	molecular_function	glycosaminoglycan binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0007399	biological_process	nervous system development
B	0008201	molecular_function	heparin binding
B	0010544	biological_process	negative regulation of platelet activation
B	0010757	biological_process	negative regulation of plasminogen activation
B	0010955	biological_process	negative regulation of protein processing
B	0030154	biological_process	cell differentiation
B	0030195	biological_process	negative regulation of blood coagulation
B	0030334	biological_process	regulation of cell migration
B	0030414	molecular_function	peptidase inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0031091	cellular_component	platelet alpha granule
B	0031594	cellular_component	neuromuscular junction
B	0045861	biological_process	negative regulation of proteolysis
B	0048711	biological_process	positive regulation of astrocyte differentiation
B	0090331	biological_process	negative regulation of platelet aggregation
B	1903561	cellular_component	extracellular vesicle

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FIVDRPFLFfI

Chain	Residue	Details
A	PHE352-ILE362

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Reactive bond","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---