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4DY0

Crystal structure of native protease nexin-1 with heparin

Functional Information from GO Data
ChainGOidnamespacecontents
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005539molecular_functionglycosaminoglycan binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005829cellular_componentcytosol
A0007399biological_processnervous system development
A0007596biological_processblood coagulation
A0008201molecular_functionheparin binding
A0008285biological_processnegative regulation of cell population proliferation
A0009611biological_processresponse to wounding
A0010544biological_processnegative regulation of platelet activation
A0010757biological_processnegative regulation of plasminogen activation
A0010766biological_processnegative regulation of sodium ion transport
A0010955biological_processnegative regulation of protein processing
A0021683biological_processcerebellar granular layer morphogenesis
A0030154biological_processcell differentiation
A0030163biological_processprotein catabolic process
A0030168biological_processplatelet activation
A0030195biological_processnegative regulation of blood coagulation
A0030308biological_processnegative regulation of cell growth
A0030334biological_processregulation of cell migration
A0031091cellular_componentplatelet alpha granule
A0031594cellular_componentneuromuscular junction
A0032940biological_processsecretion by cell
A0033363biological_processsecretory granule organization
A0042177biological_processnegative regulation of protein catabolic process
A0042628biological_processmating plug formation
A0045861biological_processnegative regulation of proteolysis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0048505biological_processregulation of timing of cell differentiation
A0048711biological_processpositive regulation of astrocyte differentiation
A0050974biological_processdetection of mechanical stimulus involved in sensory perception
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060291biological_processlong-term synaptic potentiation
A0060384biological_processinnervation
A0061108biological_processseminal vesicle epithelium development
A0062023cellular_componentcollagen-containing extracellular matrix
A0090331biological_processnegative regulation of platelet aggregation
A1903561cellular_componentextracellular vesicle
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005539molecular_functionglycosaminoglycan binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005829cellular_componentcytosol
B0007399biological_processnervous system development
B0007596biological_processblood coagulation
B0008201molecular_functionheparin binding
B0008285biological_processnegative regulation of cell population proliferation
B0009611biological_processresponse to wounding
B0010544biological_processnegative regulation of platelet activation
B0010757biological_processnegative regulation of plasminogen activation
B0010766biological_processnegative regulation of sodium ion transport
B0010955biological_processnegative regulation of protein processing
B0021683biological_processcerebellar granular layer morphogenesis
B0030154biological_processcell differentiation
B0030163biological_processprotein catabolic process
B0030168biological_processplatelet activation
B0030195biological_processnegative regulation of blood coagulation
B0030308biological_processnegative regulation of cell growth
B0030334biological_processregulation of cell migration
B0031091cellular_componentplatelet alpha granule
B0031594cellular_componentneuromuscular junction
B0032940biological_processsecretion by cell
B0033363biological_processsecretory granule organization
B0042177biological_processnegative regulation of protein catabolic process
B0042628biological_processmating plug formation
B0045861biological_processnegative regulation of proteolysis
B0045879biological_processnegative regulation of smoothened signaling pathway
B0048505biological_processregulation of timing of cell differentiation
B0048711biological_processpositive regulation of astrocyte differentiation
B0050974biological_processdetection of mechanical stimulus involved in sensory perception
B0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0060291biological_processlong-term synaptic potentiation
B0060384biological_processinnervation
B0061108biological_processseminal vesicle epithelium development
B0062023cellular_componentcollagen-containing extracellular matrix
B0090331biological_processnegative regulation of platelet aggregation
B1903561cellular_componentextracellular vesicle
Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. FIVDRPFLFfI
ChainResidueDetails
APHE352-ILE362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond => ECO:0000255
ChainResidueDetails
AARG346
BARG346

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN99
AASN140
BASN99
BASN140

221051

PDB entries from 2024-06-12

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