4DT6
Co-crystal structure of eIF4E with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0000339 | molecular_function | RNA cap binding |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0001662 | biological_process | behavioral fear response |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006412 | biological_process | translation |
| A | 0006413 | biological_process | translational initiation |
| A | 0006417 | biological_process | regulation of translation |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0010507 | biological_process | negative regulation of autophagy |
| A | 0016281 | cellular_component | eukaryotic translation initiation factor 4F complex |
| A | 0016442 | cellular_component | RISC complex |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0019827 | biological_process | stem cell population maintenance |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030182 | biological_process | neuron differentiation |
| A | 0031370 | molecular_function | eukaryotic initiation factor 4G binding |
| A | 0033391 | cellular_component | chromatoid body |
| A | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| A | 0045665 | biological_process | negative regulation of neuron differentiation |
| A | 0045931 | biological_process | positive regulation of mitotic cell cycle |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051028 | biological_process | mRNA transport |
| A | 0051168 | biological_process | nuclear export |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071549 | biological_process | cellular response to dexamethasone stimulus |
| A | 0098794 | cellular_component | postsynapse |
| A | 0098808 | molecular_function | mRNA cap binding |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099578 | biological_process | regulation of translation at postsynapse, modulating synaptic transmission |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 6LI A 1001 |
| Chain | Residue |
| A | TRP56 |
| A | LYS162 |
| A | HOH1120 |
| A | HOH1124 |
| A | HOH1126 |
| A | LEU60 |
| A | ASP90 |
| A | SER92 |
| A | PRO100 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | LYS65 |
| A | GLY97 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1003 |
| Chain | Residue |
| A | TRP73 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1004 |
| Chain | Residue |
| A | ARG181 |
| A | GLU185 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1005 |
| Chain | Residue |
| A | TYR76 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1006 |
| Chain | Residue |
| A | ASP71 |
| A | HIS78 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11879179, ECO:0000269|PubMed:12975586, ECO:0000269|PubMed:16271312 |
| Chain | Residue | Details |
| A | TRP56 | |
| A | TRP102 | |
| A | ARG157 | |
| A | THR205 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: (Microbial infection) Interaction with potato virus Y VPg => ECO:0000269|PubMed:31712417 |
| Chain | Residue | Details |
| A | LYS159 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR22 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC and MKNK2 => ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:25923732, ECO:0000269|PubMed:7665584, ECO:0000269|PubMed:7782323 |
| Chain | Residue | Details |
| A | SER209 |
