4DSS
Crystal structure of peroxiredoxin Ahp1 from Saccharomyces cerevisiae in complex with thioredoxin Trx2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005777 | cellular_component | peroxisome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0010038 | biological_process | response to metal ion |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050821 | biological_process | protein stabilization |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140824 | molecular_function | thioredoxin-dependent peroxiredoxin activity |
| B | 0000011 | biological_process | vacuole inheritance |
| B | 0000103 | biological_process | sulfate assimilation |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000324 | cellular_component | fungal-type vacuole |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0015031 | biological_process | protein transport |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0042144 | biological_process | vacuole fusion, non-autophagic |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0120124 | cellular_component | membrane fusion priming complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| B | CYS31 | |
| B | SER34 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Deprotonates C-terminal active site Cys |
| Chain | Residue | Details |
| B | ASP25 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Contributes to redox potential value |
| Chain | Residue | Details |
| B | GLY32 | |
| B | PRO33 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| B | SER62 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| B | LYS67 | |
| A | CYS120 | |
| B | LYS97 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1) => ECO:0000269|PubMed:32004955, ECO:0000269|PubMed:36102610, ECO:0000305|PubMed:21209336 |
| Chain | Residue | Details |
| A | LYS32 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1); alternate => ECO:0000269|PubMed:32004955, ECO:0000269|PubMed:36102610 |
| Chain | Residue | Details |
| A | LYS156 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1); alternate => ECO:0000269|PubMed:36102610 |
| Chain | Residue | Details |
| A | LYS48 | |
| A | LYS81 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in URM1) => ECO:0000269|PubMed:36102610 |
| Chain | Residue | Details |
| A | LYS79 | |
| A | LYS107 | |
| A | LYS124 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS113 |
