4DRP

Evaluation of Synthetic FK506 Analogs as Ligands for the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid from cocrystallization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0MD A 201

Chain	Residue
A	THR19
A	ILE87
A	TRP90
A	LYS108
A	ALA112
A	TYR113
A	ILE122
A	HOH309
A	HOH315
A	HOH324
A	HOH467
A	GLU20
A	ARG31
A	TYR57
A	PHE67
A	ASP68
A	GLY84
A	GLN85
A	VAL86

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"28147277","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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