4DRN
EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE 0MC A 201 |
Chain | Residue |
A | THR19 |
A | VAL86 |
A | ILE87 |
A | TRP90 |
A | LYS108 |
A | TYR113 |
A | SER118 |
A | ILE122 |
A | HOH305 |
A | HOH339 |
A | HOH359 |
A | GLU20 |
A | HOH461 |
A | HOH526 |
A | HOH535 |
A | ARG31 |
A | TYR57 |
A | PHE67 |
A | ASP68 |
A | PHE77 |
A | GLY84 |
A | GLN85 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:28147277 |
Chain | Residue | Details |
A | LYS28 |