4DPT
Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP and ATPgS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | LEU83 |
| A | LEU126 |
| A | ASP130 |
| A | ARG133 |
| A | HOH554 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FM0 B 401 |
| Chain | Residue |
| B | SER107 |
| B | SER139 |
| B | GLY140 |
| B | SER141 |
| B | ARG144 |
| B | SER192 |
| B | ARG193 |
| B | MET196 |
| B | MET243 |
| B | ASP283 |
| B | ALA284 |
| B | AGS402 |
| B | ALA14 |
| B | TYR18 |
| B | TRP19 |
| B | LYS21 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE AGS B 402 |
| Chain | Residue |
| B | THR43 |
| B | LEU60 |
| B | GLU69 |
| B | SER94 |
| B | ASN96 |
| B | ALA101 |
| B | ALA105 |
| B | SER106 |
| B | SER107 |
| B | ALA108 |
| B | ALA110 |
| B | SER139 |
| B | SER141 |
| B | SER192 |
| B | FM0401 |
