4DPM
Structure of malonyl-coenzyme A reductase from crenarchaeota in complex with CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | L-threonine biosynthetic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | L-threonine biosynthetic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009088 | biological_process | L-threonine biosynthetic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009088 | biological_process | L-threonine biosynthetic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
| E | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009088 | biological_process | L-threonine biosynthetic process |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0046983 | molecular_function | protein dimerization activity |
| E | 0050661 | molecular_function | NADP binding |
| E | 0051287 | molecular_function | NAD binding |
| F | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009088 | biological_process | L-threonine biosynthetic process |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0046983 | molecular_function | protein dimerization activity |
| F | 0050661 | molecular_function | NADP binding |
| F | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | TYR187 |
| A | COA402 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE COA A 402 |
| Chain | Residue |
| A | GLY42 |
| A | SER43 |
| A | THR72 |
| A | PRO86 |
| A | LEU87 |
| A | ALA91 |
| A | ASN109 |
| A | CYS153 |
| A | GLY184 |
| A | GLY186 |
| A | TYR187 |
| A | ASN335 |
| A | MG401 |
| A | HOH630 |
| A | HOH669 |
| A | HOH692 |
| A | HOH693 |
| A | HOH700 |
| A | HOH713 |
| A | HOH716 |
| A | GLY14 |
| A | HOH717 |
| A | HOH766 |
| A | THR16 |
| A | GLY17 |
| A | LEU18 |
| A | VAL19 |
| A | GLY40 |
| A | LYS41 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | TYR187 |
| B | COA402 |
| B | HOH662 |
| B | HOH693 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE COA B 402 |
| Chain | Residue |
| B | GLY14 |
| B | THR16 |
| B | GLY17 |
| B | LEU18 |
| B | VAL19 |
| B | GLY40 |
| B | LYS41 |
| B | GLY42 |
| B | SER43 |
| B | ILE69 |
| B | THR72 |
| B | PRO86 |
| B | LEU87 |
| B | ALA91 |
| B | ASN109 |
| B | CYS153 |
| B | GLY184 |
| B | GLY186 |
| B | TYR187 |
| B | ASN335 |
| B | MG401 |
| B | HOH662 |
| B | HOH666 |
| B | HOH673 |
| B | HOH677 |
| B | HOH693 |
| B | HOH698 |
| B | HOH722 |
| B | HOH743 |
| B | HOH769 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 401 |
| Chain | Residue |
| C | TYR187 |
| C | COA402 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE COA C 402 |
| Chain | Residue |
| C | GLY14 |
| C | THR16 |
| C | GLY17 |
| C | LEU18 |
| C | VAL19 |
| C | GLY40 |
| C | LYS41 |
| C | GLY42 |
| C | SER43 |
| C | THR72 |
| C | PRO86 |
| C | LEU87 |
| C | ALA91 |
| C | ASN109 |
| C | CYS153 |
| C | GLY184 |
| C | GLY186 |
| C | TYR187 |
| C | ASN335 |
| C | MG401 |
| C | HOH607 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 401 |
| Chain | Residue |
| D | TYR187 |
| D | COA402 |
| D | HOH623 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE COA D 402 |
| Chain | Residue |
| D | SER43 |
| D | THR72 |
| D | PRO86 |
| D | LEU87 |
| D | ALA91 |
| D | ASN109 |
| D | CYS153 |
| D | GLY184 |
| D | GLY186 |
| D | TYR187 |
| D | ASN335 |
| D | MG401 |
| D | HOH614 |
| D | HOH623 |
| D | HOH635 |
| D | GLY14 |
| D | THR16 |
| D | GLY17 |
| D | LEU18 |
| D | VAL19 |
| D | GLY40 |
| D | LYS41 |
| D | GLY42 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG E 401 |
| Chain | Residue |
| E | TYR187 |
| E | COA402 |
| E | HOH611 |
| E | HOH650 |
| site_id | BC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE COA E 402 |
| Chain | Residue |
| E | GLY14 |
| E | THR16 |
| E | GLY17 |
| E | LEU18 |
| E | VAL19 |
| E | GLY40 |
| E | LYS41 |
| E | GLY42 |
| E | SER43 |
| E | THR72 |
| E | PRO86 |
| E | LEU87 |
| E | ALA91 |
| E | ASN109 |
| E | CYS153 |
| E | GLY184 |
| E | GLY186 |
| E | TYR187 |
| E | ASN335 |
| E | MG401 |
| E | HOH633 |
| E | HOH650 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG F 401 |
| Chain | Residue |
| F | TYR187 |
| F | COA402 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE COA F 402 |
| Chain | Residue |
| F | GLY14 |
| F | THR16 |
| F | GLY17 |
| F | LEU18 |
| F | VAL19 |
| F | GLY40 |
| F | LYS41 |
| F | GLY42 |
| F | SER43 |
| F | THR72 |
| F | PRO86 |
| F | LEU87 |
| F | ALA91 |
| F | ASN109 |
| F | CYS153 |
| F | GLY184 |
| F | GLY186 |
| F | TYR187 |
| F | ASN335 |
| F | MG401 |
| F | HOH623 |
| F | HOH624 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
