4DPL
Structure of malonyl-coenzyme A reductase from crenarchaeota in complex with NadP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | L-threonine biosynthetic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | L-threonine biosynthetic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009088 | biological_process | L-threonine biosynthetic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009088 | biological_process | L-threonine biosynthetic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | GLY14 |
| A | PRO86 |
| A | LEU87 |
| A | PRO88 |
| A | ASN109 |
| A | SER110 |
| A | PRO111 |
| A | CYS153 |
| A | SER183 |
| A | GLY184 |
| A | GLY186 |
| A | THR16 |
| A | TYR187 |
| A | ASN335 |
| A | THR336 |
| A | GLY339 |
| A | ALA340 |
| A | HOH515 |
| A | HOH610 |
| A | HOH628 |
| A | HOH662 |
| A | HOH676 |
| A | GLY17 |
| A | LEU18 |
| A | VAL19 |
| A | LYS41 |
| A | GLY42 |
| A | SER43 |
| A | THR72 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP B 401 |
| Chain | Residue |
| B | GLY14 |
| B | THR16 |
| B | GLY17 |
| B | LEU18 |
| B | VAL19 |
| B | GLY40 |
| B | LYS41 |
| B | GLY42 |
| B | SER43 |
| B | THR72 |
| B | PRO86 |
| B | LEU87 |
| B | PRO88 |
| B | ALA91 |
| B | ASN109 |
| B | PRO111 |
| B | CYS153 |
| B | SER183 |
| B | GLY184 |
| B | GLY186 |
| B | TYR187 |
| B | ASN335 |
| B | THR336 |
| B | GLY339 |
| B | ALA340 |
| B | HOH549 |
| B | HOH557 |
| B | HOH577 |
| B | HOH624 |
| B | HOH710 |
| site_id | AC3 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NAP C 401 |
| Chain | Residue |
| C | GLY14 |
| C | THR16 |
| C | GLY17 |
| C | LEU18 |
| C | VAL19 |
| C | GLY40 |
| C | LYS41 |
| C | GLY42 |
| C | SER43 |
| C | THR72 |
| C | PRO86 |
| C | LEU87 |
| C | PRO88 |
| C | ASN109 |
| C | SER110 |
| C | PRO111 |
| C | SER183 |
| C | GLY184 |
| C | GLY186 |
| C | TYR187 |
| C | ASN335 |
| C | THR336 |
| C | GLY339 |
| C | ALA340 |
| C | HOH507 |
| C | HOH585 |
| C | HOH593 |
| C | HOH625 |
| C | HOH677 |
| C | HOH685 |
| C | HOH692 |
| C | HOH700 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAP D 401 |
| Chain | Residue |
| D | THR72 |
| D | PRO86 |
| D | LEU87 |
| D | PRO88 |
| D | ASN109 |
| D | SER110 |
| D | PRO111 |
| D | SER183 |
| D | GLY184 |
| D | GLY186 |
| D | TYR187 |
| D | ASN335 |
| D | THR336 |
| D | GLY339 |
| D | ALA340 |
| D | HOH507 |
| D | HOH568 |
| D | HOH650 |
| D | GLY14 |
| D | THR16 |
| D | GLY17 |
| D | LEU18 |
| D | VAL19 |
| D | LYS41 |
| D | GLY42 |
| D | SER43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
