4DPK
Structure of malonyl-coenzyme A reductase from crenarchaeota
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009086 | biological_process | methionine biosynthetic process |
| C | 0009088 | biological_process | threonine biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009086 | biological_process | methionine biosynthetic process |
| D | 0009088 | biological_process | threonine biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 401 |
| Chain | Residue |
| A | THR16 |
| A | GLY40 |
| A | LYS41 |
| A | GLY42 |
| A | SER43 |
| A | ILE69 |
| A | HOH582 |
| A | HOH645 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 402 |
| Chain | Residue |
| A | LEU18 |
| A | GLY186 |
| A | TYR187 |
| A | HOH608 |
| A | GLY17 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 403 |
| Chain | Residue |
| A | LEU152 |
| A | CYS153 |
| A | THR154 |
| A | GLN180 |
| A | GLY184 |
| A | TYR206 |
| A | ARG241 |
| A | HIS248 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 401 |
| Chain | Residue |
| B | THR16 |
| B | GLY40 |
| B | LYS41 |
| B | GLY42 |
| B | SER43 |
| B | ILE69 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 402 |
| Chain | Residue |
| B | GLY17 |
| B | LEU18 |
| B | GLY186 |
| B | TYR187 |
| B | HOH561 |
| B | HOH597 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 403 |
| Chain | Residue |
| B | CYS153 |
| B | THR154 |
| B | GLN180 |
| B | GLY184 |
| B | TYR206 |
| B | ARG241 |
| B | HIS248 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 C 401 |
| Chain | Residue |
| C | THR16 |
| C | GLY40 |
| C | LYS41 |
| C | GLY42 |
| C | SER43 |
| C | VAL44 |
| C | ILE69 |
| C | HOH565 |
| C | HOH604 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 C 402 |
| Chain | Residue |
| C | GLY17 |
| C | LEU18 |
| C | GLY186 |
| C | TYR187 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 C 403 |
| Chain | Residue |
| C | LEU152 |
| C | CYS153 |
| C | THR154 |
| C | GLN180 |
| C | GLY184 |
| C | TYR206 |
| C | ARG241 |
| C | HIS248 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 401 |
| Chain | Residue |
| D | THR16 |
| D | GLY40 |
| D | LYS41 |
| D | GLY42 |
| D | SER43 |
| D | VAL44 |
| D | ILE69 |
| D | HOH519 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 402 |
| Chain | Residue |
| D | GLY17 |
| D | LEU18 |
| D | GLY186 |
| D | TYR187 |
| D | HOH615 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 403 |
| Chain | Residue |
| D | CYS153 |
| D | THR154 |
| D | GLN180 |
| D | GLY184 |
| D | TYR206 |
| D | ARG241 |
| D | HIS248 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
