Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4DPF

BACE-1 in complex with a HEA-macrocyclic type inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE 0LG A 500
ChainResidue
AGLY59
AGLN121
AILE158
ATYR246
AASP276
AGLY278
ATHR279
ATHR280
AASN281
AARG283
ASER373
AGLN60
AHOH601
AHOH692
ALEU78
AASP80
AGLY82
ASER83
APRO118
ATYR119
ATHR120

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV
ChainResidueDetails
AILE77-VAL88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094
ChainResidueDetails
AASP80
AASP276

site_idSWS_FT_FI2
Number of Residues7
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:19011241
ChainResidueDetails
ALYS113
ALYS262
ALYS266
ALYS272
ALYS286
ALYS287
ALYS294

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN140
AASN159
AASN210
AASN341

224201

PDB entries from 2024-08-28

PDB statisticsPDBj update infoContact PDBjnumon