Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| B | THR255 |
| B | HOH483 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | ASP158 |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH402 |
| A | HOH411 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| B | HOH410 |
| B | HOH411 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PT A 306 |
| Chain | Residue |
| A | GLU139 |
| A | MET143 |
| A | HOH460 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS201 |
| B | HIS205 |
| B | HIS211 |
| B | NGH313 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS151 |
| B | ASP153 |
| B | HIS166 |
| B | HIS179 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP158 |
| B | GLY159 |
| B | GLY161 |
| B | VAL163 |
| B | ASP181 |
| B | GLU184 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP141 |
| B | GLY173 |
| B | ASN175 |
| B | ASP177 |
| B | HOH408 |
| B | HOH416 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | ASP107 |
| B | ASP182 |
| B | GLU184 |
| B | HOH422 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PT B 306 |
| Chain | Residue |
| B | GLU139 |
| B | MET143 |
| B | HOH500 |
| B | HOH501 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PT B 307 |
| Chain | Residue |
| B | HIS224 |
| B | CL311 |
| B | CL312 |
| B | HOH491 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PT B 308 |
| Chain | Residue |
| B | HOH494 |
| B | HOH495 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PT B 309 |
| Chain | Residue |
| B | ARG231 |
| B | ARG233 |
| B | HOH401 |
| B | HOH456 |
| B | HOH490 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PT B 310 |
| Chain | Residue |
| B | LYS94 |
| B | HOH402 |
| B | HOH403 |
| B | HOH404 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 311 |
| Chain | Residue |
| B | HIS224 |
| B | PT307 |
| B | CL312 |
| B | HOH491 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 312 |
| Chain | Residue |
| B | PT307 |
| B | CL311 |
| B | HOH491 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE NGH B 313 |
| Chain | Residue |
| B | VAL163 |
| B | LEU164 |
| B | ALA165 |
| B | HIS201 |
| B | GLU202 |
| B | HIS205 |
| B | HIS211 |
| B | PRO221 |
| B | TYR223 |
| B | ZN301 |
| B | HOH426 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
| Chain | Residue | Details |
| A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8740360","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| A | HIS201 | metal ligand |
| A | GLU202 | proton acceptor, proton donor |
| A | HIS205 | metal ligand |
| A | HIS211 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| B | HIS201 | metal ligand |
| B | GLU202 | proton acceptor, proton donor |
| B | HIS205 | metal ligand |
| B | HIS211 | metal ligand |
