4DOP

Crystal structure of the CusBA heavy-metal efflux complex from Escherichia coli, R mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005375	molecular_function	copper ion transmembrane transporter activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0006825	biological_process	copper ion transport
A	0006878	biological_process	intracellular copper ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0009636	biological_process	response to toxic substance
A	0010272	biological_process	response to silver ion
A	0010273	biological_process	detoxification of copper ion
A	0015080	molecular_function	silver ion transmembrane transporter activity
A	0015673	biological_process	silver ion transport
A	0015679	biological_process	plasma membrane copper ion transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035434	biological_process	copper ion transmembrane transport
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046688	biological_process	response to copper ion
A	0055085	biological_process	transmembrane transport
A	0060003	biological_process	copper ion export
A	1902601	biological_process	silver ion transmembrane transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PHE14-THR34
A	THR928-LEU948
A	ALA985-GLY1005
A	ILE1012-PRO1032
A	LEU338-TRP358
A	ALA363-PHE383
A	MET391-ILE411
A	VAL446-THR466
A	ALA485-ILE505
A	VAL532-TRP552
A	LYS871-PHE891
A	LEU898-MET918

---