4DO5
Pharmacological chaperones for human alpha-N-acetylgalactosaminidase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
A | 0004557 | molecular_function | alpha-galactosidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005764 | cellular_component | lysosome |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006629 | biological_process | lipid metabolic process |
A | 0008456 | molecular_function | alpha-N-acetylgalactosaminidase activity |
A | 0009311 | biological_process | oligosaccharide metabolic process |
A | 0016052 | biological_process | carbohydrate catabolic process |
A | 0016139 | biological_process | glycoside catabolic process |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0019377 | biological_process | glycolipid catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
B | 0004557 | molecular_function | alpha-galactosidase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005764 | cellular_component | lysosome |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006629 | biological_process | lipid metabolic process |
B | 0008456 | molecular_function | alpha-N-acetylgalactosaminidase activity |
B | 0009311 | biological_process | oligosaccharide metabolic process |
B | 0016052 | biological_process | carbohydrate catabolic process |
B | 0016139 | biological_process | glycoside catabolic process |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0019377 | biological_process | glycolipid catabolic process |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
site_id | PS00512 |
Number of Residues | 16 |
Details | ALPHA_GALACTOSIDASE Alpha-galactosidase signature. GYtyLnIDDc.Wigg....RD |
Chain | Residue | Details |
A | GLY71-ASP86 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | ASP156 | |
B | ASP156 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | ASP217 | |
B | ASP217 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP78 | |
B | ASP217 | |
A | LYS154 | |
A | SER188 | |
A | ARG213 | |
A | ASP217 | |
B | ASP78 | |
B | LYS154 | |
B | SER188 | |
B | ARG213 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17693683 |
Chain | Residue | Details |
A | SER322 | |
A | SER332 | |
B | SER322 | |
B | SER332 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19683538 |
Chain | Residue | Details |
A | ASN124 | |
A | ASN385 | |
B | ASN124 | |
B | ASN385 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19683538 |
Chain | Residue | Details |
A | ASN177 | |
B | ASN177 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | GLN201 | |
B | GLN201 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN359 | |
B | ASN359 |