4DNK
Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) from homo sapiens at 2.20 A resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004860 | molecular_function | protein kinase inhibitor activity |
| A | 0004864 | molecular_function | protein phosphatase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0016020 | cellular_component | membrane |
| A | 0017053 | cellular_component | transcription repressor complex |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042308 | biological_process | negative regulation of protein import into nucleus |
| A | 0042470 | cellular_component | melanosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042826 | molecular_function | histone deacetylase binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140311 | molecular_function | protein sequestering activity |
| B | 0004860 | molecular_function | protein kinase inhibitor activity |
| B | 0004864 | molecular_function | protein phosphatase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005774 | cellular_component | vacuolar membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0007165 | biological_process | signal transduction |
| B | 0008104 | biological_process | intracellular protein localization |
| B | 0016020 | cellular_component | membrane |
| B | 0017053 | cellular_component | transcription repressor complex |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042308 | biological_process | negative regulation of protein import into nucleus |
| B | 0042470 | cellular_component | melanosome |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042826 | molecular_function | histone deacetylase binding |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045296 | molecular_function | cadherin binding |
| B | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050815 | molecular_function | phosphoserine residue binding |
| B | 0051219 | molecular_function | phosphoprotein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140311 | molecular_function | protein sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| A | ARG85 |
| A | GLU89 |
| A | VAL134 |
| A | ALA135 |
| A | SER136 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | ARG20 |
| A | TYR21 |
| A | ASP22 |
| A | ASP23 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | LYS159 |
| A | ARG169 |
| A | GLU200 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | ASN185 |
| B | LYS70 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | LYS51 |
| A | GLY55 |
| A | ARG58 |
| A | TYR130 |
| A | HOH493 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 301 |
| Chain | Residue |
| B | THR2 |
| B | GLU7 |
| B | ASP225 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 302 |
| Chain | Residue |
| B | ARG85 |
| B | GLU89 |
| B | VAL134 |
| B | ALA135 |
| B | SER136 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68251","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
