4DNK
Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) from homo sapiens at 2.20 A resolution.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004860 | molecular_function | protein kinase inhibitor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005773 | cellular_component | vacuole |
A | 0005774 | cellular_component | vacuolar membrane |
A | 0005829 | cellular_component | cytosol |
A | 0005925 | cellular_component | focal adhesion |
A | 0006605 | biological_process | protein targeting |
A | 0007165 | biological_process | signal transduction |
A | 0008104 | biological_process | protein localization |
A | 0016020 | cellular_component | membrane |
A | 0019899 | molecular_function | enzyme binding |
A | 0019904 | molecular_function | protein domain specific binding |
A | 0035308 | biological_process | negative regulation of protein dephosphorylation |
A | 0042470 | cellular_component | melanosome |
A | 0042802 | molecular_function | identical protein binding |
A | 0042826 | molecular_function | histone deacetylase binding |
A | 0043085 | biological_process | positive regulation of catalytic activity |
A | 0045296 | molecular_function | cadherin binding |
A | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0050815 | molecular_function | phosphoserine residue binding |
A | 0051219 | molecular_function | phosphoprotein binding |
A | 0051220 | biological_process | cytoplasmic sequestering of protein |
A | 0070062 | cellular_component | extracellular exosome |
B | 0004860 | molecular_function | protein kinase inhibitor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005773 | cellular_component | vacuole |
B | 0005774 | cellular_component | vacuolar membrane |
B | 0005829 | cellular_component | cytosol |
B | 0005925 | cellular_component | focal adhesion |
B | 0006605 | biological_process | protein targeting |
B | 0007165 | biological_process | signal transduction |
B | 0008104 | biological_process | protein localization |
B | 0016020 | cellular_component | membrane |
B | 0019899 | molecular_function | enzyme binding |
B | 0019904 | molecular_function | protein domain specific binding |
B | 0035308 | biological_process | negative regulation of protein dephosphorylation |
B | 0042470 | cellular_component | melanosome |
B | 0042802 | molecular_function | identical protein binding |
B | 0042826 | molecular_function | histone deacetylase binding |
B | 0043085 | biological_process | positive regulation of catalytic activity |
B | 0045296 | molecular_function | cadherin binding |
B | 0045744 | biological_process | negative regulation of G protein-coupled receptor signaling pathway |
B | 0048471 | cellular_component | perinuclear region of cytoplasm |
B | 0050815 | molecular_function | phosphoserine residue binding |
B | 0051219 | molecular_function | phosphoprotein binding |
B | 0051220 | biological_process | cytoplasmic sequestering of protein |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 A 301 |
Chain | Residue |
A | ARG85 |
A | GLU89 |
A | VAL134 |
A | ALA135 |
A | SER136 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 302 |
Chain | Residue |
A | ARG20 |
A | TYR21 |
A | ASP22 |
A | ASP23 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 303 |
Chain | Residue |
A | LYS159 |
A | ARG169 |
A | GLU200 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 304 |
Chain | Residue |
A | ASN185 |
B | LYS70 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 305 |
Chain | Residue |
A | LYS51 |
A | GLY55 |
A | ARG58 |
A | TYR130 |
A | HOH493 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 B 301 |
Chain | Residue |
B | THR2 |
B | GLU7 |
B | ASP225 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 B 302 |
Chain | Residue |
B | ARG85 |
B | GLU89 |
B | VAL134 |
B | ALA135 |
B | SER136 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Interaction with phosphoserine on interacting protein => ECO:0000250 |
Chain | Residue | Details |
A | ARG58 | |
A | ARG129 | |
B | ARG58 | |
B | ARG129 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine; in 14-3-3 protein beta/alpha; alternate => ECO:0000269|Ref.7, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | MSE1 | |
B | MSE1 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR2 | |
B | THR2 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27348 |
Chain | Residue | Details |
A | LYS5 | |
B | LYS5 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P27348 |
Chain | Residue | Details |
A | LYS51 | |
B | LYS51 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CQV8 |
Chain | Residue | Details |
A | SER60 | |
B | SER60 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS70 | |
A | LYS117 | |
B | LYS70 | |
B | LYS117 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q9CQV8 |
Chain | Residue | Details |
A | TYR84 | |
A | TYR106 | |
B | TYR84 | |
B | TYR106 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68251 |
Chain | Residue | Details |
A | SER186 | |
B | SER186 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER232 | |
B | SER232 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P27348 |
Chain | Residue | Details |
A | LYS51 | |
B | LYS51 |