4DNA
CRYSTAL STRUCTURE OF putative glutathione reductase from Sinorhizobium meliloti 1021
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | ILE11 |
| A | THR42 |
| A | CYS43 |
| A | GLY47 |
| A | CYS48 |
| A | LYS51 |
| A | ARG114 |
| A | ALA115 |
| A | ALA140 |
| A | VAL141 |
| A | GLY142 |
| A | GLY12 |
| A | TYR180 |
| A | ARG266 |
| A | ASN269 |
| A | LEU273 |
| A | GLY305 |
| A | ASP306 |
| A | GLN312 |
| A | LEU313 |
| A | THR314 |
| A | PRO315 |
| A | GLY13 |
| A | HOH601 |
| A | HOH617 |
| A | HOH629 |
| B | HIS439 |
| B | PRO440 |
| A | GLY14 |
| A | SER15 |
| A | GLY16 |
| A | GLU35 |
| A | GLU36 |
| A | GLY41 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| A | HIS439 |
| A | PRO440 |
| B | ILE11 |
| B | GLY12 |
| B | GLY13 |
| B | GLY14 |
| B | SER15 |
| B | GLY16 |
| B | ALA34 |
| B | GLU35 |
| B | GLU36 |
| B | PHE37 |
| B | GLY41 |
| B | THR42 |
| B | CYS43 |
| B | CYS48 |
| B | LYS51 |
| B | THR113 |
| B | ARG114 |
| B | ALA115 |
| B | ALA140 |
| B | VAL141 |
| B | GLY142 |
| B | TYR180 |
| B | ARG266 |
| B | LEU273 |
| B | GLY305 |
| B | ASP306 |
| B | GLN312 |
| B | LEU313 |
| B | THR314 |
| B | PRO315 |
| B | HOH607 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVirGCVP |
| Chain | Residue | Details |
| A | GLY40-PRO50 |
