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4DM9

The Crystal Structure of Ubiquitin Carboxy-terminal hydrolase L1 (UCHL1) bound to a tripeptide fluoromethyl ketone Z-VAE(OMe)-FMK

Functional Information from GO Data
ChainGOidnamespacecontents
A0002176biological_processmale germ cell proliferation
A0002931biological_processresponse to ischemia
A0004197molecular_functioncysteine-type endopeptidase activity
A0004843molecular_functioncysteine-type deubiquitinase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006511biological_processubiquitin-dependent protein catabolic process
A0007409biological_processaxonogenesis
A0007412biological_processaxon target recognition
A0007628biological_processadult walking behavior
A0008234molecular_functioncysteine-type peptidase activity
A0008242molecular_functionomega peptidase activity
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016579biological_processprotein deubiquitination
A0019896biological_processaxonal transport of mitochondrion
A0030424cellular_componentaxon
A0031625molecular_functionubiquitin protein ligase binding
A0031694molecular_functionalpha-2A adrenergic receptor binding
A0042755biological_processeating behavior
A0043025cellular_componentneuronal cell body
A0043130molecular_functionubiquitin binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043407biological_processnegative regulation of MAP kinase activity
A0044306cellular_componentneuron projection terminus
A0045821biological_processpositive regulation of glycolytic process
A0050905biological_processneuromuscular process
A0055001biological_processmuscle cell development
A0071466biological_processcellular response to xenobiotic stimulus
A1904115cellular_componentaxon cytoplasm
B0002176biological_processmale germ cell proliferation
B0002931biological_processresponse to ischemia
B0004197molecular_functioncysteine-type endopeptidase activity
B0004843molecular_functioncysteine-type deubiquitinase activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006511biological_processubiquitin-dependent protein catabolic process
B0007409biological_processaxonogenesis
B0007412biological_processaxon target recognition
B0007628biological_processadult walking behavior
B0008234molecular_functioncysteine-type peptidase activity
B0008242molecular_functionomega peptidase activity
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016579biological_processprotein deubiquitination
B0019896biological_processaxonal transport of mitochondrion
B0030424cellular_componentaxon
B0031625molecular_functionubiquitin protein ligase binding
B0031694molecular_functionalpha-2A adrenergic receptor binding
B0042755biological_processeating behavior
B0043025cellular_componentneuronal cell body
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043407biological_processnegative regulation of MAP kinase activity
B0044306cellular_componentneuron projection terminus
B0045821biological_processpositive regulation of glycolytic process
B0050905biological_processneuromuscular process
B0055001biological_processmuscle cell development
B0071466biological_processcellular response to xenobiotic stimulus
B1904115cellular_componentaxon cytoplasm
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR CHAIN X OF TRIPEPTIDE FLUOROMETHYL KETONE INHIBITOR Z-VAE(OME)-FMK
ChainResidue
AMET6
ACYS90
AARG153
AASN159
APHE160
AARG178
APHE214
ASER215
AALA216
XHOH101
AVAL31
ALEU32
AGLY33
ALEU34
AGLN84
AGLY87
AASN88
ASER89

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR CHAIN Y OF TRIPEPTIDE FLUOROMETHYL KETONE INHIBITOR Z-VAE(OME)-FMK
ChainResidue
BVAL31
BLEU32
BGLY33
BLEU34
BGLN84
BGLY87
BASN88
BSER89
BCYS90
BARG153
BLYS157
BVAL158
BASN159
BPHE160
BARG178
BPHE214
YHOH101

Functional Information from PROSITE/UniProt
site_idPS00140
Number of Residues17
DetailsUCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QtigNSCGtigLIHAVA
ChainResidueDetails
AGLN84-ALA100

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:20439756
ChainResidueDetails
ACYS90
BCYS90

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:20439756
ChainResidueDetails
AHIS161
BHIS161

site_idSWS_FT_FI3
Number of Residues12
DetailsSITE: Susceptible to oxidation => ECO:0000269|PubMed:14722078
ChainResidueDetails
AMET1
AMET6
AMET12
AMET124
AMET179
ACYS220
BMET1
BMET6
BMET12
BMET124
BMET179
BCYS220

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for enzyme activity => ECO:0000269|PubMed:8639624
ChainResidueDetails
AASP176
BASP176

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q00981
ChainResidueDetails
ASER125
BSER125

site_idSWS_FT_FI6
Number of Residues2
DetailsLIPID: S-farnesyl cysteine => ECO:0000269|PubMed:19261853
ChainResidueDetails
ACYS220
BCYS220

219140

PDB entries from 2024-05-01

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