4DLC

Crystal Structure of Trypanosoma brucei dUTPase with dUMP, MgF3- transition state analogue, and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE UMP A 301

Chain	Residue
A	GLN21
A	PHE83
A	ASN212
A	ARG215
A	TYR220
A	LYS227
A	MGF302
A	MG303
A	HOH407
A	LEU24
A	ASN25
A	GLU48
A	LYS59
A	TRP60
A	TRP61
A	ASP79
A	HIS82

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MGF A 302

Chain	Residue
A	GLU48
A	GLU51
A	ASP79
A	LYS208
A	ARG215
A	LYS227
A	ASN235
A	UMP301
A	MG303
A	MG304
A	HOH404
A	HOH405
A	HOH406

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 303

Chain	Residue
A	GLU48
A	GLU51
A	UMP301
A	MGF302
A	MG304
A	HOH403
A	HOH406

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG A 304

Chain	Residue
A	GLU48
A	GLU51
A	GLU76
A	ASP79
A	MGF302
A	MG303
A	MG305
A	HOH405

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 305

Chain	Residue
A	GLU51
A	GLU76
A	MG304
A	HOH401
A	HOH402
A	HOH404
A	HOH405

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