Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4DJD

Crystal structure of folate-free corrinoid iron-sulfur protein (CFeSP) in complex with its methyltransferase (MeTr)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0008168	molecular_function	methyltransferase activity
A	0008705	molecular_function	methionine synthase activity
A	0009086	biological_process	methionine biosynthetic process
A	0015977	biological_process	carbon fixation
A	0016740	molecular_function	transferase activity
A	0031419	molecular_function	cobalamin binding
A	0032259	biological_process	methylation
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046872	molecular_function	metal ion binding
A	0050667	biological_process	homocysteine metabolic process
A	0071267	biological_process	L-methionine salvage
A	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0008168	molecular_function	methyltransferase activity
B	0008705	molecular_function	methionine synthase activity
B	0009086	biological_process	methionine biosynthetic process
B	0015977	biological_process	carbon fixation
B	0016740	molecular_function	transferase activity
B	0031419	molecular_function	cobalamin binding
B	0032259	biological_process	methylation
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046872	molecular_function	metal ion binding
B	0050667	biological_process	homocysteine metabolic process
B	0071267	biological_process	L-methionine salvage
B	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0008168	molecular_function	methyltransferase activity
C	0015977	biological_process	carbon fixation
C	0031419	molecular_function	cobalamin binding
C	0046356	biological_process	acetyl-CoA catabolic process
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0005515	molecular_function	protein binding
D	0006730	biological_process	one-carbon metabolic process
D	0015977	biological_process	carbon fixation
D	0031419	molecular_function	cobalamin binding
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0008168	molecular_function	methyltransferase activity
E	0015977	biological_process	carbon fixation
E	0031419	molecular_function	cobalamin binding
E	0046356	biological_process	acetyl-CoA catabolic process
E	0046872	molecular_function	metal ion binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	0005515	molecular_function	protein binding
F	0006730	biological_process	one-carbon metabolic process
F	0015977	biological_process	carbon fixation
F	0031419	molecular_function	cobalamin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	GLY222
A	ASP224
A	HOH427
A	HOH430
A	HOH433

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 301

Chain	Residue
B	GLY222
B	ASP224
B	HOH422
B	HOH430

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 C 501

Chain	Residue
C	PRO13
C	ASN16
C	CYS17
C	GLY18
C	CYS20
C	CYS25
C	PHE28
C	CYS42
C	PRO43

site_id	AC4
Number of Residues	24
Details	BINDING SITE FOR RESIDUE B12 C 502

Chain	Residue
B	VAL168
C	PRO318
C	VAL339
C	THR340
C	PHE343
C	LEU345
C	THR346
C	VAL350
C	GLY370
C	LEU371
C	SER372
C	VAL373
C	LEU374
C	THR375
C	ALA378
C	ASP379
C	GLY429
C	PRO430
C	ARG431
C	GLU432
C	ALA433
D	PRO188
D	LEU189
D	TYR226

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 401

Chain	Residue
D	ASP38
D	PRO42
D	PHE43
D	ILE50
D	PRO54
D	ARG235
D	LEU292
D	GLY295
D	ALA296
D	HIS297

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 402

Chain	Residue
D	ASP115
D	HOH562
F	GLY94
F	ALA95
F	ASP96
F	LYS311
F	HOH583

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 403

Chain	Residue
D	ASP115
F	ARG53
F	ASP96
F	LYS311
F	ASP315
F	HOH559

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 404

Chain	Residue
D	HIS45
D	ILE50
D	HOH507
E	GLU199
E	ASN200
E	HOH663

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 405

Chain	Residue
D	LYS122
D	GLN126
D	GLU157

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 E 501

Chain	Residue
E	PRO13
E	LYS15
E	ASN16
E	CYS17
E	GLY18
E	GLU19
E	CYS20
E	CYS25
E	CYS42

site_id	BC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE B12 E 502

Chain	Residue
E	ASP379
E	PRO408
E	PRO430
E	ARG431
E	GLU432
E	ALA433
F	PRO188
F	LEU189
F	TYR226
A	VAL168
A	ASN203
E	PRO318
E	TYR338
E	VAL339
E	THR340
E	PHE343
E	THR346
E	SER349
E	GLY370
E	LEU371
E	SER372
E	VAL373
E	LEU374
E	THR375
E	ALA378

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL E 503

Chain	Residue
D	LYS170
E	GLY210
E	LEU211
E	ASP244
E	HOH614
E	HOH655
F	TYR323

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL E 504

Chain	Residue
D	HIS144
D	SER171
D	HOH581
E	ARG240

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL F 401

Chain	Residue
F	ASP38
F	PRO42
F	PHE43
F	ILE50
F	PRO54
F	ARG235
F	LEU292
F	GLY295
F	ALA296
F	HIS297

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL F 402

Chain	Residue
D	GLU148
D	ALA175
D	HIS179
F	HIS45
F	ILE50
F	MET318

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL F 403

Chain	Residue
F	ASP8
F	ARG9
F	SER10
F	GLN240

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	Domain: {"description":"Pterin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00334","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DJE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17172470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	114
Details	Domain: {"description":"4Fe-4S","evidences":[{"source":"PROSITE-ProRule","id":"PRU00989","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22419154","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)