4DHI

Structure of C. elegans OTUB1 bound to human UBC13

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0016579	biological_process	protein deubiquitination
B	0016787	molecular_function	hydrolase activity
B	0043130	molecular_function	ubiquitin binding
D	0000151	cellular_component	ubiquitin ligase complex
D	0000166	molecular_function	nucleotide binding
D	0000209	biological_process	protein polyubiquitination
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000729	biological_process	DNA double-strand break processing
D	0001650	cellular_component	fibrillar center
D	0003723	molecular_function	RNA binding
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006301	biological_process	DNA damage tolerance
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0031371	cellular_component	ubiquitin conjugating enzyme complex
D	0031372	cellular_component	UBC13-MMS2 complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032991	cellular_component	protein-containing complex
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0045739	biological_process	positive regulation of DNA repair
D	0050852	biological_process	T cell receptor signaling pathway
D	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
D	0061631	molecular_function	ubiquitin conjugating enzyme activity
D	0070062	cellular_component	extracellular exosome
D	0070534	biological_process	protein K63-linked ubiquitination
D	0097027	molecular_function	ubiquitin-protein transferase activator activity
D	0140374	biological_process	antiviral innate immune response
D	1902523	biological_process	positive regulation of protein K63-linked ubiquitination
D	1902533	biological_process	positive regulation of intracellular signal transduction
D	1904262	biological_process	negative regulation of TORC1 signaling
D	2000781	biological_process	positive regulation of double-strand break repair

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNVdkl.GrICLdiL

Chain	Residue	Details
D	TYR76-LEU91

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	197
Details	Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q96DC9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"Q96DC9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q96FW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5VVQ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	146
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"16112642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16122702","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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