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4DGC

TRIMCyp cyclophilin domain from Macaca mulatta: cyclosporin A complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0001933biological_processnegative regulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005178molecular_functionintegrin binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006469biological_processnegative regulation of protein kinase activity
A0006915biological_processapoptotic process
A0016018molecular_functioncyclosporin A binding
A0016853molecular_functionisomerase activity
A0030168biological_processplatelet activation
A0030593biological_processneutrophil chemotaxis
A0030595biological_processleukocyte chemotaxis
A0032148biological_processactivation of protein kinase B activity
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032991cellular_componentprotein-containing complex
A0034389biological_processlipid droplet organization
A0034599biological_processcellular response to oxidative stress
A0042118biological_processendothelial cell activation
A0043410biological_processpositive regulation of MAPK cascade
A0045069biological_processregulation of viral genome replication
A0045070biological_processpositive regulation of viral genome replication
A0050714biological_processpositive regulation of protein secretion
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0060352biological_processcell adhesion molecule production
A0061944biological_processnegative regulation of protein K48-linked ubiquitination
A0070527biological_processplatelet aggregation
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1903901biological_processnegative regulation of viral life cycle
A1904399molecular_functionheparan sulfate binding
A2001233biological_processregulation of apoptotic signaling pathway
B0000413biological_processprotein peptidyl-prolyl isomerization
B0001933biological_processnegative regulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005178molecular_functionintegrin binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006457biological_processprotein folding
B0006469biological_processnegative regulation of protein kinase activity
B0006915biological_processapoptotic process
B0016018molecular_functioncyclosporin A binding
B0016853molecular_functionisomerase activity
B0030168biological_processplatelet activation
B0030593biological_processneutrophil chemotaxis
B0030595biological_processleukocyte chemotaxis
B0032148biological_processactivation of protein kinase B activity
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032991cellular_componentprotein-containing complex
B0034389biological_processlipid droplet organization
B0034599biological_processcellular response to oxidative stress
B0042118biological_processendothelial cell activation
B0043410biological_processpositive regulation of MAPK cascade
B0045069biological_processregulation of viral genome replication
B0045070biological_processpositive regulation of viral genome replication
B0050714biological_processpositive regulation of protein secretion
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0060352biological_processcell adhesion molecule production
B0061944biological_processnegative regulation of protein K48-linked ubiquitination
B0070527biological_processplatelet aggregation
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1903901biological_processnegative regulation of viral life cycle
B1904399molecular_functionheparan sulfate binding
B2001233biological_processregulation of apoptotic signaling pathway
C0000413biological_processprotein peptidyl-prolyl isomerization
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005178molecular_functionintegrin binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006457biological_processprotein folding
C0006469biological_processnegative regulation of protein kinase activity
C0006915biological_processapoptotic process
C0016018molecular_functioncyclosporin A binding
C0016853molecular_functionisomerase activity
C0030168biological_processplatelet activation
C0030593biological_processneutrophil chemotaxis
C0030595biological_processleukocyte chemotaxis
C0032148biological_processactivation of protein kinase B activity
C0032873biological_processnegative regulation of stress-activated MAPK cascade
C0032991cellular_componentprotein-containing complex
C0034389biological_processlipid droplet organization
C0034599biological_processcellular response to oxidative stress
C0042118biological_processendothelial cell activation
C0043410biological_processpositive regulation of MAPK cascade
C0045069biological_processregulation of viral genome replication
C0045070biological_processpositive regulation of viral genome replication
C0050714biological_processpositive regulation of protein secretion
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0060352biological_processcell adhesion molecule production
C0061944biological_processnegative regulation of protein K48-linked ubiquitination
C0070527biological_processplatelet aggregation
C1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1903901biological_processnegative regulation of viral life cycle
C1904399molecular_functionheparan sulfate binding
C2001233biological_processregulation of apoptotic signaling pathway
D0000413biological_processprotein peptidyl-prolyl isomerization
D0001933biological_processnegative regulation of protein phosphorylation
D0001934biological_processpositive regulation of protein phosphorylation
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005178molecular_functionintegrin binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006457biological_processprotein folding
D0006469biological_processnegative regulation of protein kinase activity
D0006915biological_processapoptotic process
D0016018molecular_functioncyclosporin A binding
D0016853molecular_functionisomerase activity
D0030168biological_processplatelet activation
D0030593biological_processneutrophil chemotaxis
D0030595biological_processleukocyte chemotaxis
D0032148biological_processactivation of protein kinase B activity
D0032873biological_processnegative regulation of stress-activated MAPK cascade
D0032991cellular_componentprotein-containing complex
D0034389biological_processlipid droplet organization
D0034599biological_processcellular response to oxidative stress
D0042118biological_processendothelial cell activation
D0043410biological_processpositive regulation of MAPK cascade
D0045069biological_processregulation of viral genome replication
D0045070biological_processpositive regulation of viral genome replication
D0050714biological_processpositive regulation of protein secretion
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0060352biological_processcell adhesion molecule production
D0061944biological_processnegative regulation of protein K48-linked ubiquitination
D0070527biological_processplatelet aggregation
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1903901biological_processnegative regulation of viral life cycle
D1904399molecular_functionheparan sulfate binding
D2001233biological_processregulation of apoptotic signaling pathway
E0000413biological_processprotein peptidyl-prolyl isomerization
E0001933biological_processnegative regulation of protein phosphorylation
E0001934biological_processpositive regulation of protein phosphorylation
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005178molecular_functionintegrin binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006457biological_processprotein folding
E0006469biological_processnegative regulation of protein kinase activity
E0006915biological_processapoptotic process
E0016018molecular_functioncyclosporin A binding
E0016853molecular_functionisomerase activity
E0030168biological_processplatelet activation
E0030593biological_processneutrophil chemotaxis
E0030595biological_processleukocyte chemotaxis
E0032148biological_processactivation of protein kinase B activity
E0032873biological_processnegative regulation of stress-activated MAPK cascade
E0032991cellular_componentprotein-containing complex
E0034389biological_processlipid droplet organization
E0034599biological_processcellular response to oxidative stress
E0042118biological_processendothelial cell activation
E0043410biological_processpositive regulation of MAPK cascade
E0045069biological_processregulation of viral genome replication
E0045070biological_processpositive regulation of viral genome replication
E0050714biological_processpositive regulation of protein secretion
E0051092biological_processpositive regulation of NF-kappaB transcription factor activity
E0060352biological_processcell adhesion molecule production
E0061944biological_processnegative regulation of protein K48-linked ubiquitination
E0070527biological_processplatelet aggregation
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1903901biological_processnegative regulation of viral life cycle
E1904399molecular_functionheparan sulfate binding
E2001233biological_processregulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR CHAIN F OF CYCLOSPORIN A
ChainResidue
AARG55
AALA103
AGLN111
APHE113
ATRP121
AHIS126
CLYS31
CTYR79
FHOH101
APHE60
AGLN63
AASN71
AGLY72
ATHR73
AGLU81
AALA101
AASN102

site_idAC2
Number of Residues21
DetailsBINDING SITE FOR CHAIN G OF CYCLOSPORIN A
ChainResidue
APRO30
ATYR79
BARG55
BPHE60
BGLN63
BALA101
BASN102
BALA103
BGLN111
BPHE113
BTRP121
BHIS126
CGLY72
CTHR73
CGLU81
CALA103
GHOH101
GHOH102
HABA6
HSAR7
HMLE8

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR CHAIN H OF CYCLOSPORIN A
ChainResidue
BGLY74
BGLU81
BALA103
CARG55
CPHE60
CGLN63
CALA101
CASN102
CALA103
CGLN111
CPHE113
CTRP121
CHIS126
DLYS31
DTYR79
GABA6
GSAR7
GMLE8
HHOH101

site_idAC4
Number of Residues18
DetailsBINDING SITE FOR CHAIN I OF CYCLOSPORIN A
ChainResidue
DARG55
DPHE60
DGLN63
DALA101
DASN102
DALA103
DGLN111
DPHE113
DTRP121
DHIS126
EPRO30
ELYS31
ETYR79
EGLU81
EALA103
JABA6
JSAR7
JMLE8

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR CHAIN J OF CYCLOSPORIN A
ChainResidue
BLYS31
BTYR79
DTHR73
DGLU81
EARG55
EPHE60
EGLN63
EALA101
EASN102
EGLN111
EPHE113
ETRP121
EHIS126
IABA6
ISAR7
IMLE8

Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG
ChainResidueDetails
ATYR48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues156
DetailsDomain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues5
DetailsModified residue: {"description":"N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues10
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues5
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues5
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues5
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P17742","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues5
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues5
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P62937","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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