Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0008237 | molecular_function | metallopeptidase activity |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 501 |
| Chain | Residue |
| A | ALA58 |
| A | GLU172 |
| A | CYS175 |
| A | ASP177 |
| A | GLU275 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | HIS311 |
| A | HIS315 |
| A | ASP322 |
| A | HOH683 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 503 |
| Chain | Residue |
| A | GLU323 |
| A | CYS398 |
| A | CYS409 |
| A | CYS412 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2PE A 504 |
| Chain | Residue |
| A | TYR286 |
| A | GLY288 |
| A | HIS311 |
| A | GLU312 |
| A | TYR324 |
| A | TYR326 |
| A | TYR386 |
| A | ASN403 |
| A | HOH826 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 505 |
| Chain | Residue |
| A | HIS241 |
| A | ARG261 |
| A | HOH723 |
| A | HOH802 |
| B | HIS153 |
| B | LYS155 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A 506 |
| Chain | Residue |
| A | HIS153 |
| A | LYS155 |
| A | ASP267 |
| A | HOH676 |
| A | HOH712 |
| A | HOH858 |
| B | HIS241 |
| B | ARG261 |
| B | HOH772 |
| B | HOH850 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 507 |
| Chain | Residue |
| A | HIS62 |
| A | HIS63 |
| A | GLU66 |
| A | HOH810 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 508 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 501 |
| Chain | Residue |
| B | ALA58 |
| B | GLU172 |
| B | CYS175 |
| B | ASP177 |
| B | GLU275 |
| B | HOH836 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | HIS311 |
| B | HIS315 |
| B | ASP322 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 503 |
| Chain | Residue |
| B | GLU323 |
| B | CYS398 |
| B | CYS409 |
| B | CYS412 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 2PE B 504 |
| Chain | Residue |
| B | GLU100 |
| B | ARG255 |
| B | TYR256 |
| B | TYR286 |
| B | GLY288 |
| B | HIS311 |
| B | GLU312 |
| B | TYR324 |
| B | PHE325 |
| B | ASN403 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 505 |
| Chain | Residue |
| B | HIS62 |
| B | HIS63 |
| B | LEU64 |
| B | HOH907 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 506 |
| Chain | Residue |
| B | THR114 |
| B | ASN266 |
| B | GLU275 |
| B | ILE277 |
| B | ASN293 |
| B | ALA294 |
| B | HOH644 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 507 |
| Chain | Residue |
| B | GLU53 |
| B | PRO147 |
| B | HOH825 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 508 |
| Chain | Residue |
| B | ASN72 |
| B | SER92 |
| B | ILE291 |
| B | TYR292 |
| B | GLY319 |
| B | LEU320 |
| B | TRP342 |
| B | GLU343 |
| B | HOH609 |
| B | HOH933 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 509 |
| Chain | Residue |
| B | ARG349 |
| B | PRO367 |
| B | HOH859 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 510 |
| Chain | Residue |
| B | THR283 |
| B | GLU284 |
| B | HOH918 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 511 |
| Chain | Residue |
| B | HIS163 |
| E | GLU136 |
| E | VAL137 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 512 |
| Chain | Residue |
| B | ASN133 |
| B | LYS134 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 513 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 514 |
| Chain | Residue |
| B | PHE352 |
| B | ALA353 |
| B | HOH676 |
| B | HOH793 |
| D | ASN215 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 501 |
| Chain | Residue |
| C | ALA58 |
| C | GLU172 |
| C | CYS175 |
| C | ASP177 |
| C | GLU275 |
| C | HOH670 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 502 |
| Chain | Residue |
| C | HIS311 |
| C | HIS315 |
| C | ASP322 |
| C | HOH950 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 503 |
| Chain | Residue |
| C | GLU323 |
| C | CYS398 |
| C | CYS409 |
| C | CYS412 |
| site_id | CC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 2PE C 504 |
| Chain | Residue |
| C | TYR256 |
| C | TYR286 |
| C | GLY288 |
| C | HIS311 |
| C | GLU312 |
| C | TYR324 |
| C | PHE325 |
| C | TYR386 |
| C | ASN403 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 505 |
| Chain | Residue |
| C | HIS241 |
| C | ARG261 |
| C | HOH727 |
| C | HOH820 |
| C | HOH853 |
| D | HIS153 |
| D | LYS155 |
| site_id | DC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 506 |
| Chain | Residue |
| C | SER169 |
| C | GLY170 |
| C | GLN174 |
| D | ARG135 |
| D | GLU340 |
| D | GLN344 |
| D | ASN351 |
| D | SER354 |
| D | HOH744 |
| D | HOH845 |
| site_id | DC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 507 |
| Chain | Residue |
| C | ASN72 |
| C | SER92 |
| C | ILE291 |
| C | TYR292 |
| C | TRP342 |
| C | GLU343 |
| C | HOH713 |
| C | HOH795 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 508 |
| Chain | Residue |
| C | HIS62 |
| C | HIS63 |
| C | LEU64 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 509 |
| Chain | Residue |
| C | THR114 |
| C | VAL262 |
| C | ASN266 |
| C | GLU275 |
| C | ALA294 |
| C | HOH612 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 510 |
| Chain | Residue |
| C | PRO68 |
| C | GLN344 |
| C | HOH617 |
| C | HOH819 |
| C | HOH884 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 511 |
| Chain | Residue |
| C | HIS247 |
| C | SER260 |
| C | HOH636 |
| D | ASP49 |
| D | GLU50 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 512 |
| Chain | Residue |
| C | THR158 |
| C | HIS159 |
| C | ILE160 |
| D | LYS43 |
| site_id | DC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 513 |
| Chain | Residue |
| C | THR283 |
| C | GLU284 |
| site_id | DC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA D 501 |
| Chain | Residue |
| D | ALA58 |
| D | GLU172 |
| D | CYS175 |
| D | ASP177 |
| D | GLU275 |
| D | HOH746 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 502 |
| Chain | Residue |
| D | HIS311 |
| D | HIS315 |
| D | ASP322 |
| D | HOH826 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 503 |
| Chain | Residue |
| D | GLU323 |
| D | CYS398 |
| D | CYS409 |
| D | CYS412 |
| site_id | EC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 2PE D 504 |
| Chain | Residue |
| D | TYR256 |
| D | TYR286 |
| D | GLY288 |
| D | HIS311 |
| D | GLU312 |
| D | TYR324 |
| D | PHE325 |
| D | TYR326 |
| D | TYR386 |
| D | ARG401 |
| D | ASN403 |
| D | HOH982 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 D 505 |
| Chain | Residue |
| C | LYS155 |
| C | HOH783 |
| D | HIS241 |
| D | ARG261 |
| D | HOH702 |
| D | HOH790 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 506 |
| Chain | Residue |
| D | HIS62 |
| D | HIS63 |
| D | LEU64 |
| D | HOH842 |
| site_id | EC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 507 |
| Chain | Residue |
| B | GLU136 |
| B | VAL137 |
| D | HIS163 |
| D | GLY271 |
| D | HOH749 |
| D | HOH782 |
| D | HOH801 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 508 |
| Chain | Residue |
| C | GLU103 |
| C | LYS109 |
| D | GLU50 |
| D | LEU51 |
| D | ASP149 |
| D | LEU151 |
| site_id | EC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 509 |
| Chain | Residue |
| D | THR114 |
| D | VAL262 |
| D | ASN266 |
| D | GLU275 |
| D | ASN293 |
| D | ALA294 |
| site_id | EC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL D 510 |
| Chain | Residue |
| D | ASN72 |
| D | SER92 |
| D | ILE291 |
| D | TYR292 |
| D | GLY319 |
| D | LEU320 |
| D | TRP342 |
| D | GLU343 |
| D | GOL515 |
| D | HOH671 |
| D | HOH822 |
| site_id | FC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 511 |
| Chain | Residue |
| B | ARG135 |
| B | GLU340 |
| B | PRO341 |
| B | SER354 |
| B | LYS355 |
| D | SER169 |
| D | GLY170 |
| D | GLN174 |
| D | HOH786 |
| site_id | FC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 512 |
| Chain | Residue |
| C | ASN215 |
| D | ARG349 |
| D | ILE350 |
| D | ASN351 |
| D | PHE352 |
| D | ALA353 |
| D | GLU357 |
| site_id | FC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 513 |
| Chain | Residue |
| D | ARG418 |
| D | GLU421 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 514 |
| Chain | Residue |
| D | THR158 |
| D | HIS159 |
| D | ILE160 |
| D | HOH967 |
| site_id | FC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 515 |
| Chain | Residue |
| D | GLU97 |
| D | TYR256 |
| D | GLY289 |
| D | GLY290 |
| D | GLU312 |
| D | HIS315 |
| D | GOL510 |
| D | HOH822 |
| D | HOH826 |
| site_id | FC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 516 |
| Chain | Residue |
| D | THR283 |
| D | GLU284 |
| site_id | FC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 517 |
| site_id | FC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 518 |
| site_id | FC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 519 |
| Chain | Residue |
| D | ARG349 |
| D | HOH925 |
| site_id | GC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 520 |
| Chain | Residue |
| D | SER212 |
| D | LYS214 |
| D | ASN215 |
| site_id | GC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA E 501 |
| Chain | Residue |
| E | ALA58 |
| E | GLU172 |
| E | CYS175 |
| E | ASP177 |
| E | GLU275 |
| site_id | GC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 502 |
| Chain | Residue |
| E | HIS311 |
| E | HIS315 |
| E | ASP322 |
| E | HOH857 |
| site_id | GC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 503 |
| Chain | Residue |
| E | GLU323 |
| E | CYS398 |
| E | CYS409 |
| E | CYS412 |
| site_id | GC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2PE E 504 |
| Chain | Residue |
| E | TYR286 |
| E | HIS311 |
| E | GLU312 |
| E | TYR324 |
| E | PHE325 |
| E | TYR326 |
| E | ARG401 |
| E | ASN403 |
| site_id | GC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 505 |
| Chain | Residue |
| E | HIS241 |
| E | ARG261 |
| E | HOH653 |
| E | HOH800 |
| F | HIS153 |
| F | LYS155 |
| F | ASP267 |
| site_id | GC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL E 506 |
| Chain | Residue |
| E | SER92 |
| E | ILE291 |
| E | TYR292 |
| E | GLY319 |
| E | LEU320 |
| E | TRP342 |
| E | GLU343 |
| E | HOH604 |
| site_id | GC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 507 |
| Chain | Residue |
| B | SER169 |
| B | GLY170 |
| B | GLN174 |
| E | ARG135 |
| E | GLU340 |
| E | GLN344 |
| E | SER354 |
| site_id | GC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL E 508 |
| Chain | Residue |
| A | THR27 |
| A | ASN28 |
| E | THR158 |
| E | HIS159 |
| E | HOH651 |
| site_id | HC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 509 |
| Chain | Residue |
| E | THR114 |
| E | ASN266 |
| E | GLU275 |
| E | ILE277 |
| E | ASN293 |
| E | ALA294 |
| E | HOH605 |
| site_id | HC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL E 510 |
| Chain | Residue |
| E | HIS62 |
| E | HIS63 |
| E | LEU64 |
| E | GLU66 |
| site_id | HC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 511 |
| site_id | HC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA F 501 |
| Chain | Residue |
| F | ALA58 |
| F | GLU172 |
| F | CYS175 |
| F | ASP177 |
| F | GLU275 |
| site_id | HC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 502 |
| Chain | Residue |
| F | HIS311 |
| F | HIS315 |
| F | ASP322 |
| F | HOH885 |
| site_id | HC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 503 |
| Chain | Residue |
| F | GLU323 |
| F | CYS398 |
| F | CYS409 |
| F | CYS412 |
| site_id | HC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 2PE F 504 |
| Chain | Residue |
| F | ARG255 |
| F | TYR286 |
| F | GLY288 |
| F | GLU312 |
| F | TYR324 |
| F | PHE325 |
| F | TYR326 |
| F | ASN403 |
| site_id | HC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL F 505 |
| Chain | Residue |
| F | SER92 |
| F | ILE291 |
| F | TYR292 |
| F | LEU320 |
| F | TYR335 |
| F | TRP342 |
| F | GLU343 |
| F | HOH659 |
| site_id | HC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL F 506 |
| Chain | Residue |
| F | GLN20 |
| F | HIS62 |
| F | HIS63 |
| F | LEU64 |
| site_id | IC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL F 507 |
| Chain | Residue |
| F | THR158 |
| F | HIS159 |
| F | HOH679 |
| F | HOH859 |
| site_id | IC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL F 508 |
| Chain | Residue |
| F | THR283 |
| F | GLU284 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVVHEFGHSF |
| Chain | Residue | Details |
| A | VAL308-PHE317 | |
