4DF1
Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus complexed with inhibitor BMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE BMP A 301 |
| Chain | Residue |
| A | ASP12 |
| A | ARG179 |
| A | HOH402 |
| A | HOH403 |
| A | HOH405 |
| A | HOH414 |
| A | HOH417 |
| A | HOH423 |
| B | ASP64 |
| B | VAL65 |
| B | HIS67 |
| A | LYS33 |
| A | ASP59 |
| A | LYS61 |
| A | MET106 |
| A | THR107 |
| A | PRO155 |
| A | GLN160 |
| A | GLY178 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A 302 |
| Chain | Residue |
| A | CYS82 |
| A | CYS83 |
| A | ARG127 |
| A | PRO202 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE BMP B 301 |
| Chain | Residue |
| A | ASP64 |
| A | VAL65 |
| A | HIS67 |
| B | ASP12 |
| B | LYS33 |
| B | ASP59 |
| B | LYS61 |
| B | MET106 |
| B | THR107 |
| B | PRO155 |
| B | GLN160 |
| B | GLY178 |
| B | ARG179 |
| B | HOH403 |
| B | HOH404 |
| B | HOH405 |
| B | HOH406 |
| B | HOH417 |
| B | HOH425 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B 302 |
| Chain | Residue |
| B | CYS82 |
| B | CYS83 |
| B | ARG127 |
