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4DBE

Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0016831molecular_functioncarboxy-lyase activity
A0044205biological_process'de novo' UMP biosynthetic process
B0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
B0005829cellular_componentcytosol
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0016831molecular_functioncarboxy-lyase activity
B0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE BMP A 301
ChainResidue
AASP11
AARG188
AHOH402
AHOH403
AHOH405
AHOH408
AHOH411
BASP64
BILE65
BILE68
ALYS30
AASP59
ALYS61
AMET114
ASER115
APRO164
AGLN169
AGLY187

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 302
ChainResidue
AGLY40
AVAL41
AASP42
AHOH461
BGLY40
BHOH406
BHOH421

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 303
ChainResidue
AARG99
AASP102
AALA103
AGLY167
AGLY170
AGLY171
AHOH455

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 304
ChainResidue
AALA193
AGLY194
AASN195
ATHR198
AALA199

site_idAC5
Number of Residues20
DetailsBINDING SITE FOR RESIDUE BMP B 301
ChainResidue
AASP64
AILE65
AILE68
BALA9
BASP11
BLYS30
BASP59
BLYS61
BMET114
BSER115
BPRO164
BGLN169
BILE185
BGLY187
BARG188
BHOH404
BHOH405
BHOH409
BHOH410
BHOH411

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 302
ChainResidue
BARG99
BSER168
BARG188
BHOH432
BHOH459

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PDB entries from 2024-10-30

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