4DBE
Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE BMP A 301 |
| Chain | Residue |
| A | ASP11 |
| A | ARG188 |
| A | HOH402 |
| A | HOH403 |
| A | HOH405 |
| A | HOH408 |
| A | HOH411 |
| B | ASP64 |
| B | ILE65 |
| B | ILE68 |
| A | LYS30 |
| A | ASP59 |
| A | LYS61 |
| A | MET114 |
| A | SER115 |
| A | PRO164 |
| A | GLN169 |
| A | GLY187 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | GLY40 |
| A | VAL41 |
| A | ASP42 |
| A | HOH461 |
| B | GLY40 |
| B | HOH406 |
| B | HOH421 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | ARG99 |
| A | ASP102 |
| A | ALA103 |
| A | GLY167 |
| A | GLY170 |
| A | GLY171 |
| A | HOH455 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | ALA193 |
| A | GLY194 |
| A | ASN195 |
| A | THR198 |
| A | ALA199 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE BMP B 301 |
| Chain | Residue |
| A | ASP64 |
| A | ILE65 |
| A | ILE68 |
| B | ALA9 |
| B | ASP11 |
| B | LYS30 |
| B | ASP59 |
| B | LYS61 |
| B | MET114 |
| B | SER115 |
| B | PRO164 |
| B | GLN169 |
| B | ILE185 |
| B | GLY187 |
| B | ARG188 |
| B | HOH404 |
| B | HOH405 |
| B | HOH409 |
| B | HOH410 |
| B | HOH411 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | ARG99 |
| B | SER168 |
| B | ARG188 |
| B | HOH432 |
| B | HOH459 |
