4DBE
Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE BMP A 301 |
Chain | Residue |
A | ASP11 |
A | ARG188 |
A | HOH402 |
A | HOH403 |
A | HOH405 |
A | HOH408 |
A | HOH411 |
B | ASP64 |
B | ILE65 |
B | ILE68 |
A | LYS30 |
A | ASP59 |
A | LYS61 |
A | MET114 |
A | SER115 |
A | PRO164 |
A | GLN169 |
A | GLY187 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 302 |
Chain | Residue |
A | GLY40 |
A | VAL41 |
A | ASP42 |
A | HOH461 |
B | GLY40 |
B | HOH406 |
B | HOH421 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 303 |
Chain | Residue |
A | ARG99 |
A | ASP102 |
A | ALA103 |
A | GLY167 |
A | GLY170 |
A | GLY171 |
A | HOH455 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 304 |
Chain | Residue |
A | ALA193 |
A | GLY194 |
A | ASN195 |
A | THR198 |
A | ALA199 |
site_id | AC5 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE BMP B 301 |
Chain | Residue |
A | ASP64 |
A | ILE65 |
A | ILE68 |
B | ALA9 |
B | ASP11 |
B | LYS30 |
B | ASP59 |
B | LYS61 |
B | MET114 |
B | SER115 |
B | PRO164 |
B | GLN169 |
B | ILE185 |
B | GLY187 |
B | ARG188 |
B | HOH404 |
B | HOH405 |
B | HOH409 |
B | HOH410 |
B | HOH411 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 302 |
Chain | Residue |
B | ARG99 |
B | SER168 |
B | ARG188 |
B | HOH432 |
B | HOH459 |