4DBE

Crystal structure of orotidine 5'-monophosphate decarboxylase from Sulfolobus solfataricus complexed with inhibitor BMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
B	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BMP A 301

Chain	Residue
A	ASP11
A	ARG188
A	HOH402
A	HOH403
A	HOH405
A	HOH408
A	HOH411
B	ASP64
B	ILE65
B	ILE68
A	LYS30
A	ASP59
A	LYS61
A	MET114
A	SER115
A	PRO164
A	GLN169
A	GLY187

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	GLY40
A	VAL41
A	ASP42
A	HOH461
B	GLY40
B	HOH406
B	HOH421

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 303

Chain	Residue
A	ARG99
A	ASP102
A	ALA103
A	GLY167
A	GLY170
A	GLY171
A	HOH455

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 304

Chain	Residue
A	ALA193
A	GLY194
A	ASN195
A	THR198
A	ALA199

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site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE BMP B 301

Chain	Residue
A	ASP64
A	ILE65
A	ILE68
B	ALA9
B	ASP11
B	LYS30
B	ASP59
B	LYS61
B	MET114
B	SER115
B	PRO164
B	GLN169
B	ILE185
B	GLY187
B	ARG188
B	HOH404
B	HOH405
B	HOH409
B	HOH410
B	HOH411

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	ARG99
B	SER168
B	ARG188
B	HOH432
B	HOH459

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