4DAR

Crystal structure of the hexameric purine nucleoside phosphorylase from Bacillus subtilis in complex with tubercidin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042278	biological_process	purine nucleoside metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TBN A 301

Chain	Residue
A	HIS4
A	SER202
A	ASP203
A	ARG87
A	SER90
A	GLY92
A	PHE159
A	VAL177
A	GLU178
A	MET179
A	GLU180

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Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GtGMGvPSiSIyvnEL

Chain	Residue	Details
A	GLY61-LEU76

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ASP203

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P50389

Chain	Residue	Details
A	HIS4
A	ARG43

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P50389

Chain	Residue	Details
A	GLY20
A	ARG24
A	ARG87
A	GLU178
A	SER202

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ARG216

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