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4D8N

Human Kallikrein 6 Inhibitors with a para-Amidobenzylanmine P1 Group Carry a High Binding Efficiency

Functional Information from GO Data
ChainGOidnamespacecontents
A0001533cellular_componentcornified envelope
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0006508biological_processproteolysis
A0007417biological_processcentral nervous system development
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009611biological_processresponse to wounding
A0010975biological_processregulation of neuron projection development
A0016540biological_processprotein autoprocessing
A0030141cellular_componentsecretory granule
A0030574biological_processcollagen catabolic process
A0031965cellular_componentnuclear membrane
A0042246biological_processtissue regeneration
A0042445biological_processhormone metabolic process
A0042552biological_processmyelination
A0042982biological_processamyloid precursor protein metabolic process
A0045171cellular_componentintercellular bridge
A0045595biological_processregulation of cell differentiation
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 0HM A 301
ChainResidue
ALEU41
ASER195
AVAL213
ASER214
ATRP215
AGLY216
AASN217
ACYS220
ACYS42
AHIS57
AASP189
ASER190
ACYS191
AGLN192
AGLY193
AASP194

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:12016211
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by autolysis
ChainResidueDetails
AGLN76

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN132

224572

PDB entries from 2024-09-04

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