Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE BXD A 501 |
| Chain | Residue |
| A | GLN12 |
| A | THR72 |
| A | GLN73 |
| A | PHE108 |
| A | ILE110 |
| A | ARG128 |
| A | TYR187 |
| A | ASP217 |
| A | GLY219 |
| A | THR220 |
| A | THR221 |
| A | GLY13 |
| A | HOH617 |
| A | HOH647 |
| A | HOH705 |
| A | HOH719 |
| A | HOH733 |
| A | LEU30 |
| A | ASP32 |
| A | GLY34 |
| A | SER35 |
| A | VAL69 |
| A | PRO70 |
| A | TYR71 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE BXD B 501 |
| Chain | Residue |
| B | GLN12 |
| B | GLY13 |
| B | LEU30 |
| B | ASP32 |
| B | GLY34 |
| B | SER35 |
| B | VAL69 |
| B | PRO70 |
| B | TYR71 |
| B | THR72 |
| B | GLN73 |
| B | PHE108 |
| B | ILE110 |
| B | TYR187 |
| B | ASP217 |
| B | GLY219 |
| B | THR220 |
| B | THR221 |
| B | HOH646 |
| B | HOH679 |
| B | HOH704 |
| B | HOH754 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 502 |
| Chain | Residue |
| B | ARG96 |
| B | ALA97 |
| B | ASN98 |
| B | GLU134 |
| B | SER139 |
| B | GLN143 |
| B | HOH664 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE BXD C 401 |
| Chain | Residue |
| C | GLN12 |
| C | GLY13 |
| C | LEU30 |
| C | ASP32 |
| C | GLY34 |
| C | SER35 |
| C | VAL69 |
| C | PRO70 |
| C | TYR71 |
| C | THR72 |
| C | GLN73 |
| C | PHE108 |
| C | ILE110 |
| C | ASP221 |
| C | GLY223 |
| C | THR224 |
| C | THR225 |
| C | HOH514 |
| C | HOH603 |
| C | HOH633 |
| C | HOH727 |
| C | HOH745 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 402 |
| Chain | Residue |
| C | GLU283 |
| C | ARG342 |
| C | ARG344 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE29-VAL40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
