4D85

Crystal Structure of Human Beta Secretase in Complex with NVP-BVI151

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 0GU A 401

Chain	Residue
A	GLY13
A	PHE110
A	ILE112
A	ARG130
A	TYR190
A	ASP220
A	GLY222
A	THR223
A	THR224
A	ARG227
A	HOH524
A	ASP34
A	HOH593
A	GLY36
A	SER37
A	PRO72
A	TYR73
A	THR74
A	GLN75
A	GLY76

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 402

Chain	Residue
A	THR105

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV

Chain	Residue	Details
A	ILE31-VAL42

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP34
A	ASP220

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site_id	SWS_FT_FI2
Number of Residues	7
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17425515, ECO:0000269|PubMed:19011241

Chain	Residue	Details
A	LYS67
A	LYS206
A	LYS210
A	LYS216
A	LYS230
A	LYS231
A	LYS238

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN94
A	ASN113
A	ASN159
A	ASN285

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