4D7L
Methionine sulfoxide reductase A of Corynebacterium diphtheriae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008113 | molecular_function | peptide-methionine (S)-S-oxide reductase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0033744 | molecular_function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0036456 | molecular_function | L-methionine-(S)-S-oxide reductase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008113 | molecular_function | peptide-methionine (S)-S-oxide reductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0033744 | molecular_function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0036456 | molecular_function | L-methionine-(S)-S-oxide reductase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008113 | molecular_function | peptide-methionine (S)-S-oxide reductase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0033744 | molecular_function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0036456 | molecular_function | L-methionine-(S)-S-oxide reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC A 1220 |
| Chain | Residue |
| A | CYS52 |
| A | TYR53 |
| A | TRP54 |
| A | TYR83 |
| A | GLU95 |
| A | TYR135 |
| A | PRO207 |
| A | CYS215 |
| A | HOH2172 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1221 |
| Chain | Residue |
| A | TYR205 |
| A | TYR205 |
| A | PRO207 |
| A | PRO207 |
| A | HIS208 |
| A | HIS208 |
| A | HIS209 |
| A | HIS209 |
| A | SER210 |
| A | SER210 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 1222 |
| Chain | Residue |
| A | ALA167 |
| A | GLY168 |
| B | PRO8 |
| B | GLN123 |
| B | TYR125 |
| B | ARG126 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 1223 |
| Chain | Residue |
| A | THR36 |
| A | LEU37 |
| A | ARG38 |
| A | GLY39 |
| A | GLN40 |
| A | VAL67 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 1224 |
| Chain | Residue |
| A | LYS18 |
| A | GLY20 |
| A | PRO21 |
| A | PRO79 |
| A | HOH2254 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 1225 |
| Chain | Residue |
| A | THR82 |
| A | ARG84 |
| A | GLU85 |
| A | HOH2135 |
| A | HOH2222 |
| A | HOH2255 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 1226 |
| Chain | Residue |
| A | MET116 |
| A | HIS119 |
| A | PRO121 |
| A | TYR160 |
| A | LEU164 |
| B | ARG9 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE A 1227 |
| Chain | Residue |
| A | THR43 |
| A | GLU44 |
| A | THR45 |
| A | HOH2081 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE A 1228 |
| Chain | Residue |
| A | GLU147 |
| A | PRO178 |
| A | SER181 |
| A | HOH2210 |
| A | HOH2257 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE A 1229 |
| Chain | Residue |
| A | ASN129 |
| A | ASP130 |
| A | THR131 |
| A | HIS208 |
| A | GLY212 |
| A | ALA214 |
| A | CYS215 |
| A | GLY216 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC B 1220 |
| Chain | Residue |
| B | CYS52 |
| B | TYR53 |
| B | TRP54 |
| B | TYR83 |
| B | GLU95 |
| B | TYR135 |
| B | PRO207 |
| B | HOH2137 |
| C | CYS215 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1221 |
| Chain | Residue |
| B | TYR205 |
| B | PRO207 |
| B | HIS208 |
| B | HIS209 |
| B | SER210 |
| C | TYR205 |
| C | PRO207 |
| C | HIS208 |
| C | HIS209 |
| C | SER210 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 1222 |
| Chain | Residue |
| A | VAL11 |
| A | HOH2006 |
| A | HOH2016 |
| B | PRO144 |
| B | HOH2202 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 1223 |
| Chain | Residue |
| B | LEU25 |
| B | PRO26 |
| B | ASN27 |
| B | ASP192 |
| B | HOH2203 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE B 1224 |
| Chain | Residue |
| B | HOH2100 |
| B | ARG38 |
| B | TYR187 |
| B | TYR188 |
| B | MET189 |
| B | HOH2029 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGE B 1225 |
| Chain | Residue |
| A | GLY168 |
| A | HOH2201 |
| B | THR122 |
| B | LEU169 |
| B | GLY170 |
| B | ARG171 |
| B | THR173 |
| C | SO41221 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE B 1226 |
| Chain | Residue |
| B | ALA165 |
| B | ALA166 |
| B | HOH2159 |
| C | ARG171 |
| C | ILE172 |
| C | HOH2157 |
| C | HOH2159 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE B 1227 |
| Chain | Residue |
| B | ALA167 |
| C | ALA7 |
| C | PRO8 |
| C | TYR125 |
| C | ARG126 |
| C | HOH2118 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE B 1228 |
| Chain | Residue |
| B | GLY212 |
| B | ALA214 |
| B | GLY216 |
| C | ASN129 |
| C | ASP130 |
| C | THR131 |
| C | HIS208 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PGE B 1229 |
| Chain | Residue |
| B | ASN129 |
| B | ASP130 |
| B | THR131 |
| B | HIS208 |
| C | GLY212 |
| C | VAL213 |
| C | ALA214 |
| C | CYS215 |
| C | GLY216 |
| site_id | CC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC C 1220 |
| Chain | Residue |
| B | CYS215 |
| B | HOH2201 |
| C | CYS52 |
| C | TYR53 |
| C | TRP54 |
| C | TYR83 |
| C | GLU95 |
| C | TYR135 |
| C | PRO207 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1221 |
| Chain | Residue |
| B | PGE1225 |
| C | GLY170 |
| C | ARG171 |
| C | HOH2155 |
| C | HOH2190 |
| C | HOH2191 |
| C | HOH2192 |
| C | HOH2193 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1222 |
| Chain | Residue |
| A | ARG152 |
| C | ALA142 |
| C | GLY143 |
| C | HOH2194 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE C 1223 |
| Chain | Residue |
| B | ASN27 |
| B | HOH2032 |
| C | THR36 |
| C | LEU37 |
| C | ARG38 |
| C | GLY39 |
| C | GLN40 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE C 1224 |
| Chain | Residue |
| C | GLN29 |
| C | PRO30 |
| C | ASP192 |
| C | GLN195 |
| C | GLN196 |
| C | LYS200 |
| C | HOH2030 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE C 1225 |
| Chain | Residue |
| C | TYR187 |
| C | HOH2057 |
| C | HOH2169 |
| C | HOH2170 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01401 |
| Chain | Residue | Details |
| A | CYS52 | |
| B | CYS52 | |
| C | CYS52 |
