4D60

Structure of a dimeric Plasmodium falciparum profilin mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0003785	molecular_function	actin monomer binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005938	cellular_component	cell cortex
A	0008289	molecular_function	lipid binding
A	0015629	cellular_component	actin cytoskeleton
A	0030036	biological_process	actin cytoskeleton organization
A	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
B	0003779	molecular_function	actin binding
B	0003785	molecular_function	actin monomer binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005938	cellular_component	cell cortex
B	0008289	molecular_function	lipid binding
B	0015629	cellular_component	actin cytoskeleton
B	0030036	biological_process	actin cytoskeleton organization
B	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
C	0003779	molecular_function	actin binding
C	0003785	molecular_function	actin monomer binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005938	cellular_component	cell cortex
C	0008289	molecular_function	lipid binding
C	0015629	cellular_component	actin cytoskeleton
C	0030036	biological_process	actin cytoskeleton organization
C	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
D	0003779	molecular_function	actin binding
D	0003785	molecular_function	actin monomer binding
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005938	cellular_component	cell cortex
D	0008289	molecular_function	lipid binding
D	0015629	cellular_component	actin cytoskeleton
D	0030036	biological_process	actin cytoskeleton organization
D	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
E	0003779	molecular_function	actin binding
E	0003785	molecular_function	actin monomer binding
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005938	cellular_component	cell cortex
E	0008289	molecular_function	lipid binding
E	0015629	cellular_component	actin cytoskeleton
E	0030036	biological_process	actin cytoskeleton organization
E	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
F	0003779	molecular_function	actin binding
F	0003785	molecular_function	actin monomer binding
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005938	cellular_component	cell cortex
F	0008289	molecular_function	lipid binding
F	0015629	cellular_component	actin cytoskeleton
F	0030036	biological_process	actin cytoskeleton organization
F	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
G	0003779	molecular_function	actin binding
G	0003785	molecular_function	actin monomer binding
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005938	cellular_component	cell cortex
G	0008289	molecular_function	lipid binding
G	0015629	cellular_component	actin cytoskeleton
G	0030036	biological_process	actin cytoskeleton organization
G	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
H	0003779	molecular_function	actin binding
H	0003785	molecular_function	actin monomer binding
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005938	cellular_component	cell cortex
H	0008289	molecular_function	lipid binding
H	0015629	cellular_component	actin cytoskeleton
H	0030036	biological_process	actin cytoskeleton organization
H	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
I	0003779	molecular_function	actin binding
I	0003785	molecular_function	actin monomer binding
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005938	cellular_component	cell cortex
I	0008289	molecular_function	lipid binding
I	0015629	cellular_component	actin cytoskeleton
I	0030036	biological_process	actin cytoskeleton organization
I	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
J	0003779	molecular_function	actin binding
J	0003785	molecular_function	actin monomer binding
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005938	cellular_component	cell cortex
J	0008289	molecular_function	lipid binding
J	0015629	cellular_component	actin cytoskeleton
J	0030036	biological_process	actin cytoskeleton organization
J	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
K	0003779	molecular_function	actin binding
K	0003785	molecular_function	actin monomer binding
K	0005515	molecular_function	protein binding
K	0005543	molecular_function	phospholipid binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005938	cellular_component	cell cortex
K	0008289	molecular_function	lipid binding
K	0015629	cellular_component	actin cytoskeleton
K	0030036	biological_process	actin cytoskeleton organization
K	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
L	0003779	molecular_function	actin binding
L	0003785	molecular_function	actin monomer binding
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005938	cellular_component	cell cortex
L	0008289	molecular_function	lipid binding
L	0015629	cellular_component	actin cytoskeleton
L	0030036	biological_process	actin cytoskeleton organization
L	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
M	0003779	molecular_function	actin binding
M	0003785	molecular_function	actin monomer binding
M	0005515	molecular_function	protein binding
M	0005543	molecular_function	phospholipid binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005938	cellular_component	cell cortex
M	0008289	molecular_function	lipid binding
M	0015629	cellular_component	actin cytoskeleton
M	0030036	biological_process	actin cytoskeleton organization
M	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
N	0003779	molecular_function	actin binding
N	0003785	molecular_function	actin monomer binding
N	0005515	molecular_function	protein binding
N	0005543	molecular_function	phospholipid binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005938	cellular_component	cell cortex
N	0008289	molecular_function	lipid binding
N	0015629	cellular_component	actin cytoskeleton
N	0030036	biological_process	actin cytoskeleton organization
N	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
O	0003779	molecular_function	actin binding
O	0003785	molecular_function	actin monomer binding
O	0005515	molecular_function	protein binding
O	0005543	molecular_function	phospholipid binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005938	cellular_component	cell cortex
O	0008289	molecular_function	lipid binding
O	0015629	cellular_component	actin cytoskeleton
O	0030036	biological_process	actin cytoskeleton organization
O	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility
P	0003779	molecular_function	actin binding
P	0003785	molecular_function	actin monomer binding
P	0005515	molecular_function	protein binding
P	0005543	molecular_function	phospholipid binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005938	cellular_component	cell cortex
P	0008289	molecular_function	lipid binding
P	0015629	cellular_component	actin cytoskeleton
P	0030036	biological_process	actin cytoskeleton organization
P	0060327	biological_process	cytoplasmic actin-based contraction involved in cell motility

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1165

Chain	Residue
A	GLU81
A	GLY82
A	ARG102

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1166

Chain	Residue
A	ASN99
A	GLU101
A	LYS150
D	ARG146
D	LYS150

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 1165

Chain	Residue
B	LYS50

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1166

Chain	Residue
B	ASN99
B	GLU101
B	ARG146
B	LYS150
E	ARG146
E	LYS150

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1165

Chain	Residue
C	GLU101
C	LYS150
I	GLU101
I	LYS150

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 N 1165

Chain	Residue
K	GLU101
K	ARG146
N	ASN99
N	ARG146
N	LYS150

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 1165

Chain	Residue
J	GLU101
J	LYS150
L	GLU101
L	ARG146
L	LYS150

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 K 1165

Chain	Residue
C	ASN80
C	GLU81
K	ASN80
K	GLU81

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Region: {"description":"Pro-rich sequence-binding","evidences":[{"source":"UniProtKB","id":"P86294","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	256
Details	Region: {"description":"Actin-binding","evidences":[{"source":"UniProtKB","id":"P86294","evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	96
Details	Motif: {"description":"Plasmodium-specific profilin mini-domain","evidences":[{"source":"UniProtKB","id":"P86294","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Site: {"description":"Interaction with Pro-rich sequence","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Site: {"description":"Interaction with actin","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---