4D50
Structure of human deoxyhypusine hydroxylase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008612 | biological_process | peptidyl-lysine modification to peptidyl-hypusine |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019135 | molecular_function | deoxyhypusine monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008612 | biological_process | peptidyl-lysine modification to peptidyl-hypusine |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019135 | molecular_function | deoxyhypusine monooxygenase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A 301 |
| Chain | Residue |
| A | HIS89 |
| A | GLU90 |
| A | HIS207 |
| A | PER303 |
| A | HOH2001 |
| A | HOH2003 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A 302 |
| Chain | Residue |
| A | PER303 |
| A | HOH2002 |
| A | HOH2003 |
| A | HIS56 |
| A | HIS240 |
| A | GLU241 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PER A 303 |
| Chain | Residue |
| A | HIS56 |
| A | HIS89 |
| A | GLU90 |
| A | HIS207 |
| A | MET237 |
| A | HIS240 |
| A | GLU241 |
| A | FE301 |
| A | FE302 |
| A | HOH2003 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GAI A 404 |
| Chain | Residue |
| A | GLU274 |
| A | LEU277 |
| A | ASP278 |
| A | HOH2227 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GAI A 405 |
| Chain | Residue |
| A | GLU4 |
| A | PRO37 |
| A | GLU188 |
| B | LEU145 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI A 406 |
| Chain | Residue |
| A | THR233 |
| A | GLU234 |
| A | HOH2255 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI A 407 |
| Chain | Residue |
| A | GLY36 |
| A | PRO37 |
| A | ILE40 |
| A | ASP67 |
| A | ARG69 |
| A | HOH2060 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE B 301 |
| Chain | Residue |
| B | HIS89 |
| B | GLU90 |
| B | HIS207 |
| B | FE302 |
| B | PER303 |
| B | HOH2001 |
| B | HOH2003 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE B 302 |
| Chain | Residue |
| B | HIS56 |
| B | HIS240 |
| B | GLU241 |
| B | FE301 |
| B | PER303 |
| B | HOH2002 |
| B | HOH2003 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PER B 303 |
| Chain | Residue |
| B | HIS56 |
| B | MET86 |
| B | HIS89 |
| B | GLU90 |
| B | HIS207 |
| B | MET237 |
| B | HIS240 |
| B | GLU241 |
| B | FE301 |
| B | FE302 |
| B | HOH2003 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI B 404 |
| Chain | Residue |
| A | LEU145 |
| B | GLU4 |
| B | GLY36 |
| B | PRO37 |
| B | GLU188 |
| B | HOH2025 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03101","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16533814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D50","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
