4D4Z
STRUCTURE OF HUMAN DEOXYHYPUSINE HYDROXYLASE in complex with glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008612 | biological_process | peptidyl-lysine modification to peptidyl-hypusine |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019135 | molecular_function | deoxyhypusine monooxygenase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008612 | biological_process | peptidyl-lysine modification to peptidyl-hypusine |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019135 | molecular_function | deoxyhypusine monooxygenase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A 301 |
| Chain | Residue |
| A | HIS89 |
| A | GLU90 |
| A | HIS207 |
| A | FE302 |
| A | OH303 |
| A | GOL305 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE A 302 |
| Chain | Residue |
| A | FE301 |
| A | OH303 |
| A | GOL305 |
| A | HOH2001 |
| A | HIS56 |
| A | HIS240 |
| A | GLU241 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OH A 303 |
| Chain | Residue |
| A | HIS56 |
| A | HIS89 |
| A | GLU90 |
| A | HIS207 |
| A | MET237 |
| A | GLU241 |
| A | FE301 |
| A | FE302 |
| A | GOL305 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | HIS56 |
| A | HIS89 |
| A | GLU90 |
| A | GLU93 |
| A | HIS207 |
| A | GLU208 |
| A | GLU241 |
| A | FE301 |
| A | FE302 |
| A | OH303 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE B3P A 306 |
| Chain | Residue |
| A | PHE47 |
| A | ASP48 |
| A | ASP76 |
| A | ASP80 |
| A | GLN83 |
| A | HOH2058 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE B 301 |
| Chain | Residue |
| B | HIS89 |
| B | GLU90 |
| B | HIS207 |
| B | FE302 |
| B | OH303 |
| B | GOL305 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE B 302 |
| Chain | Residue |
| B | HIS56 |
| B | HIS240 |
| B | GLU241 |
| B | FE301 |
| B | OH303 |
| B | GOL305 |
| B | HOH2001 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OH B 303 |
| Chain | Residue |
| B | HIS56 |
| B | HIS89 |
| B | GLU90 |
| B | HIS207 |
| B | GLU241 |
| B | FE301 |
| B | FE302 |
| B | GOL305 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 305 |
| Chain | Residue |
| B | HIS56 |
| B | HIS89 |
| B | GLU90 |
| B | GLU93 |
| B | HIS207 |
| B | GLU208 |
| B | GLU241 |
| B | FE301 |
| B | FE302 |
| B | OH303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 52 |
| Details | Repeat: {"description":"HEAT-like PBS-type 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03101","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16533814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25865244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D50","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
