4D2J

Crystal structure of F16BP Aldolase from Toxoplasma gondii (TgALD1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005737	cellular_component	cytoplasm
A	0006096	biological_process	glycolytic process
A	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 1422

Chain	Residue
A	SER267
A	ASP269
A	ASP269
A	HIS307
A	CYS311
A	HOH2145

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1417

Chain	Residue
A	LYS177
A	HOH2044
A	ASP104
A	SER106
A	THR109

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1418

Chain	Residue
A	ARG113
A	GLY373
A	ARG374
A	HOH2138
A	HOH2158
A	HOH2160

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1419

Chain	Residue
A	LYS177
A	VAL178
A	ASP179
A	ARG203
A	TYR207

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 1420

Chain	Residue
A	THR184
A	SER201

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1421

Chain	Residue
A	ASN121
A	GLU123

---

Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGaLLKPN

Chain	Residue	Details
A	VAL293-ASN303

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000303|PubMed:28972169

Chain	Residue	Details
A	GLU259

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with dihydroxyacetone phosphate => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC

Chain	Residue	Details
A	LYS301

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL

Chain	Residue	Details
A	ASP104
A	SER106
A	SER343
A	GLY344
A	GLY373
A	ARG374

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TKC, ECO:0007744|PDB:5TKL

Chain	Residue	Details
A	THR109

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00883

Chain	Residue	Details
A	ARG113
A	SER371

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3, ECO:0007744|PDB:5TKC

Chain	Residue	Details
A	LYS177
A	GLU259
A	LYS301

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:28972169, ECO:0007744|PDB:5TK3

Chain	Residue	Details
A	LYS216

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