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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4D19

Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0005777	cellular_component	peroxisome
A	0006144	biological_process	purine nucleobase metabolic process
A	0006145	biological_process	purine nucleobase catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019628	biological_process	urate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IUP A 1297

Chain	Residue
A	ILE54
A	GLN228
A	ASN254
A	GLY286
A	ILE288
A	OXY1299
A	HOH2437
A	HOH2616
A	ALA56
A	THR57
A	ASP58
A	PHE159
A	LEU170
A	ARG176
A	SER226
A	VAL227

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 1298

Chain	Residue
A	GLN158
A	TRP174
A	HOH2463
A	HOH2515

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OXY A 1299

Chain	Residue
A	THR57
A	ASN254
A	HIS256
A	GLY286
A	ILE288
A	IUP1297

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LtVLKSTnSqFwgFlrdeYttLketwdR

Chain	Residue	Details
A	LEU149-ARG176

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:24466188, ECO:0007744\|PDB:4N3M, ECO:0007744\|PDB:4N9M, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V

Chain	Residue	Details
A	LYS10
A	THR57
A	HIS256

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	THR57

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S

Chain	Residue	Details
A	ASP58

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	PHE159

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	ARG176

site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	VAL227

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305\|PubMed:9360612, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FUB, ECO:0007744\|PDB:2IBA, ECO:0007744\|PDB:2IC0, ECO:0007744\|PDB:2ICQ, ECO:0007744\|PDB:2PES, ECO:0007744\|PDB:2ZKA, ECO:0007744\|PDB:2ZKB, ECO:0007744\|PDB:3BK8, ECO:0007744\|PDB:3CKS, ECO:0007744\|PDB:3CKU, ECO:0007744\|PDB:3F2M, ECO:0007744\|PDB:3GKO, ECO:0007744\|PDB:3L8W, ECO:0007744\|PDB:3LBG, ECO:0007744\|PDB:3LD4, ECO:0007744\|PDB:3P9F, ECO:0007744\|PDB:3PJK, ECO:0007744\|PDB:3PK3, ECO:0007744\|PDB:3PK4, ECO:0007744\|PDB:3PK5, ECO:0007744\|PDB:3PK6, ECO:0007744\|PDB:3PK8, ECO:0007744\|PDB:3PKF, ECO:0007744\|PDB:3PKG, ECO:0007744\|PDB:3PKH, ECO:0007744\|PDB:3PKK, ECO:0007744\|PDB:3PKL, ECO:0007744\|PDB:3PKS, ECO:0007744\|PDB:3PKT, ECO:0007744\|PDB:3PKU, ECO:0007744\|PDB:3PLE, ECO:0007744\|PDB:3PLG, ECO:0007744\|PDB:3PLH, ECO:0007744\|PDB:3PLI, ECO:0007744\|PDB:3PLJ, ECO:0007744\|PDB:3PLM, ECO:0007744\|PDB:4CW0, ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6, ECO:0007744\|PDB:4N9S, ECO:0007744\|PDB:4N9V, ECO:0007744\|PDB:4OP6, ECO:0007744\|PDB:4OP9, ECO:0007744\|PDB:5FRC

Chain	Residue	Details
A	GLN228

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744\|PDB:4CW2, ECO:0007744\|PDB:4CW3, ECO:0007744\|PDB:4CW6

Chain	Residue	Details
A	ASN254

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000305\|PubMed:1339455, ECO:0007744\|PDB:1R4S, ECO:0007744\|PDB:1R4U, ECO:0007744\|PDB:1R51, ECO:0007744\|PDB:1R56, ECO:0007744\|PDB:1WRR, ECO:0007744\|PDB:1WS2, ECO:0007744\|PDB:1WS3, ECO:0007744\|PDB:1XT4, ECO:0007744\|PDB:1XXJ, ECO:0007744\|PDB:1XY3, ECO:0007744\|PDB:2FXL, ECO:0007744\|PDB:3BJP, ECO:0007744\|PDB:4FSK

Chain	Residue	Details
A	SER1

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 118

Chain	Residue	Details
A	LYS10	hydrogen bond donor, proton acceptor, proton donor, proton relay
A	THR57	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay
A	ARG176	electrostatic stabiliser
A	GLN228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS256	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay

227111

PDB entries from 2024-11-06

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