4D0L

Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000922	cellular_component	spindle pole
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005771	cellular_component	multivesicular body
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005813	cellular_component	centrosome
B	0005814	cellular_component	centriole
B	0005828	cellular_component	kinetochore microtubule
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006887	biological_process	exocytosis
B	0007080	biological_process	mitotic metaphase chromosome alignment
B	0008017	molecular_function	microtubule binding
B	0010008	cellular_component	endosome membrane
B	0010634	biological_process	positive regulation of epithelial cell migration
B	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0019905	molecular_function	syntaxin binding
B	0030133	cellular_component	transport vesicle
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0030666	cellular_component	endocytic vesicle membrane
B	0030672	cellular_component	synaptic vesicle membrane
B	0030953	biological_process	astral microtubule organization
B	0031175	biological_process	neuron projection development
B	0031410	cellular_component	cytoplasmic vesicle
B	0031489	molecular_function	myosin V binding
B	0031982	cellular_component	vesicle
B	0032154	cellular_component	cleavage furrow
B	0032402	biological_process	melanosome transport
B	0032465	biological_process	regulation of cytokinesis
B	0032588	cellular_component	trans-Golgi network membrane
B	0032991	cellular_component	protein-containing complex
B	0034394	biological_process	protein localization to cell surface
B	0036258	biological_process	multivesicular body assembly
B	0043001	biological_process	Golgi to plasma membrane protein transport
B	0045335	cellular_component	phagocytic vesicle
B	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
B	0048227	biological_process	plasma membrane to endosome transport
B	0051223	biological_process	regulation of protein transport
B	0051650	biological_process	establishment of vesicle localization
B	0051959	molecular_function	dynein light intermediate chain binding
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0060627	biological_process	regulation of vesicle-mediated transport
B	0061502	biological_process	early endosome to recycling endosome transport
B	0061512	biological_process	protein localization to cilium
B	0070062	cellular_component	extracellular exosome
B	0071806	biological_process	protein transmembrane transport
B	0072594	biological_process	establishment of protein localization to organelle
B	0072659	biological_process	protein localization to plasma membrane
B	0090150	biological_process	establishment of protein localization to membrane
B	0090307	biological_process	mitotic spindle assembly
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098830	cellular_component	presynaptic endosome
B	0098837	cellular_component	postsynaptic recycling endosome
B	0098876	biological_process	vesicle-mediated transport to the plasma membrane
B	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
B	0098978	cellular_component	glutamatergic synapse
B	0099003	biological_process	vesicle-mediated transport in synapse
B	0099532	biological_process	synaptic vesicle endosomal processing
B	0150093	biological_process	amyloid-beta clearance by transcytosis
B	1902017	biological_process	regulation of cilium assembly
B	1902954	biological_process	regulation of early endosome to recycling endosome transport
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1903438	biological_process	positive regulation of mitotic cytokinetic process
B	1904779	biological_process	regulation of protein localization to centrosome
B	1990182	biological_process	exosomal secretion
B	2001135	biological_process	regulation of endocytic recycling
C	0016301	molecular_function	kinase activity
C	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0000922	cellular_component	spindle pole
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005771	cellular_component	multivesicular body
D	0005794	cellular_component	Golgi apparatus
D	0005802	cellular_component	trans-Golgi network
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005828	cellular_component	kinetochore microtubule
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006887	biological_process	exocytosis
D	0007080	biological_process	mitotic metaphase chromosome alignment
D	0008017	molecular_function	microtubule binding
D	0010008	cellular_component	endosome membrane
D	0010634	biological_process	positive regulation of epithelial cell migration
D	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0016192	biological_process	vesicle-mediated transport
D	0016787	molecular_function	hydrolase activity
D	0019905	molecular_function	syntaxin binding
D	0030133	cellular_component	transport vesicle
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0030666	cellular_component	endocytic vesicle membrane
D	0030672	cellular_component	synaptic vesicle membrane
D	0030953	biological_process	astral microtubule organization
D	0031175	biological_process	neuron projection development
D	0031410	cellular_component	cytoplasmic vesicle
D	0031489	molecular_function	myosin V binding
D	0031982	cellular_component	vesicle
D	0032154	cellular_component	cleavage furrow
D	0032402	biological_process	melanosome transport
D	0032465	biological_process	regulation of cytokinesis
D	0032588	cellular_component	trans-Golgi network membrane
D	0032991	cellular_component	protein-containing complex
D	0034394	biological_process	protein localization to cell surface
D	0036258	biological_process	multivesicular body assembly
D	0043001	biological_process	Golgi to plasma membrane protein transport
D	0045335	cellular_component	phagocytic vesicle
D	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
D	0048227	biological_process	plasma membrane to endosome transport
D	0051223	biological_process	regulation of protein transport
D	0051650	biological_process	establishment of vesicle localization
D	0051959	molecular_function	dynein light intermediate chain binding
D	0055037	cellular_component	recycling endosome
D	0055038	cellular_component	recycling endosome membrane
D	0060627	biological_process	regulation of vesicle-mediated transport
D	0061502	biological_process	early endosome to recycling endosome transport
D	0061512	biological_process	protein localization to cilium
D	0070062	cellular_component	extracellular exosome
D	0071806	biological_process	protein transmembrane transport
D	0072594	biological_process	establishment of protein localization to organelle
D	0072659	biological_process	protein localization to plasma membrane
D	0090150	biological_process	establishment of protein localization to membrane
D	0090307	biological_process	mitotic spindle assembly
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098830	cellular_component	presynaptic endosome
D	0098837	cellular_component	postsynaptic recycling endosome
D	0098876	biological_process	vesicle-mediated transport to the plasma membrane
D	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
D	0098978	cellular_component	glutamatergic synapse
D	0099003	biological_process	vesicle-mediated transport in synapse
D	0099532	biological_process	synaptic vesicle endosomal processing
D	0150093	biological_process	amyloid-beta clearance by transcytosis
D	1902017	biological_process	regulation of cilium assembly
D	1902954	biological_process	regulation of early endosome to recycling endosome transport
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1903438	biological_process	positive regulation of mitotic cytokinetic process
D	1904779	biological_process	regulation of protein localization to centrosome
D	1990182	biological_process	exosomal secretion
D	2001135	biological_process	regulation of endocytic recycling
E	0016301	molecular_function	kinase activity
E	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
F	0000139	cellular_component	Golgi membrane
F	0000166	molecular_function	nucleotide binding
F	0000922	cellular_component	spindle pole
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005771	cellular_component	multivesicular body
F	0005794	cellular_component	Golgi apparatus
F	0005802	cellular_component	trans-Golgi network
F	0005813	cellular_component	centrosome
F	0005814	cellular_component	centriole
F	0005828	cellular_component	kinetochore microtubule
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006887	biological_process	exocytosis
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0008017	molecular_function	microtubule binding
F	0010008	cellular_component	endosome membrane
F	0010634	biological_process	positive regulation of epithelial cell migration
F	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
F	0015031	biological_process	protein transport
F	0016020	cellular_component	membrane
F	0016192	biological_process	vesicle-mediated transport
F	0016787	molecular_function	hydrolase activity
F	0019905	molecular_function	syntaxin binding
F	0030133	cellular_component	transport vesicle
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0030666	cellular_component	endocytic vesicle membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0030953	biological_process	astral microtubule organization
F	0031175	biological_process	neuron projection development
F	0031410	cellular_component	cytoplasmic vesicle
F	0031489	molecular_function	myosin V binding
F	0031982	cellular_component	vesicle
F	0032154	cellular_component	cleavage furrow
F	0032402	biological_process	melanosome transport
F	0032465	biological_process	regulation of cytokinesis
F	0032588	cellular_component	trans-Golgi network membrane
F	0032991	cellular_component	protein-containing complex
F	0034394	biological_process	protein localization to cell surface
F	0036258	biological_process	multivesicular body assembly
F	0043001	biological_process	Golgi to plasma membrane protein transport
F	0045335	cellular_component	phagocytic vesicle
F	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
F	0048227	biological_process	plasma membrane to endosome transport
F	0051223	biological_process	regulation of protein transport
F	0051650	biological_process	establishment of vesicle localization
F	0051959	molecular_function	dynein light intermediate chain binding
F	0055037	cellular_component	recycling endosome
F	0055038	cellular_component	recycling endosome membrane
F	0060627	biological_process	regulation of vesicle-mediated transport
F	0061502	biological_process	early endosome to recycling endosome transport
F	0061512	biological_process	protein localization to cilium
F	0070062	cellular_component	extracellular exosome
F	0071806	biological_process	protein transmembrane transport
F	0072594	biological_process	establishment of protein localization to organelle
F	0072659	biological_process	protein localization to plasma membrane
F	0090150	biological_process	establishment of protein localization to membrane
F	0090307	biological_process	mitotic spindle assembly
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098830	cellular_component	presynaptic endosome
F	0098837	cellular_component	postsynaptic recycling endosome
F	0098876	biological_process	vesicle-mediated transport to the plasma membrane
F	0098887	biological_process	neurotransmitter receptor transport, endosome to postsynaptic membrane
F	0098978	cellular_component	glutamatergic synapse
F	0099003	biological_process	vesicle-mediated transport in synapse
F	0099532	biological_process	synaptic vesicle endosomal processing
F	0150093	biological_process	amyloid-beta clearance by transcytosis
F	1902017	biological_process	regulation of cilium assembly
F	1902954	biological_process	regulation of early endosome to recycling endosome transport
F	1903078	biological_process	positive regulation of protein localization to plasma membrane
F	1903438	biological_process	positive regulation of mitotic cytokinetic process
F	1904779	biological_process	regulation of protein localization to centrosome
F	1990182	biological_process	exosomal secretion
F	2001135	biological_process	regulation of endocytic recycling

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 093 A 2002

Chain	Residue
A	LEU374
A	ASP674
A	PRO381
A	ILE547
A	LYS549
A	TYR583
A	PRO597
A	VAL598
A	ALA601
A	ILE673

---

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GSP B 2000

Chain	Residue
A	GLY155
B	SER20
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	ASN26
B	PHE36
B	ASN37
B	LEU38
B	SER42
B	THR43
B	ALA68
B	GLY69
B	ASN124
B	LYS125
B	ASP127
B	LEU128
B	SER154
B	ALA155
B	LEU156
B	MG2001
B	HOH3001

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2001

Chain	Residue
B	SER25
B	THR43
B	GSP2000
B	HOH3001

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 093 C 2002

Chain	Residue
C	PRO381
C	ILE547
C	LYS549
C	TYR583
C	PRO597
C	VAL598
C	ALA601
C	LEU663
C	ILE673
C	ASP674

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GSP D 2000

Chain	Residue
D	SER20
D	GLY21
D	GLY23
D	LYS24
D	SER25
D	ASN26
D	PHE36
D	ASN37
D	LEU38
D	SER40
D	THR43
D	GLY69
D	ASN124
D	LYS125
D	ASP127
D	LEU128
D	SER154
D	ALA155
D	LEU156
D	MG2001

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG D 2001

Chain	Residue
D	SER25
D	THR43
D	GSP2000

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 093 E 2002

Chain	Residue
E	PRO381
E	ILE547
E	LYS549
E	TYR583
E	PRO597
E	VAL598
E	ALA601
E	ILE673
E	ASP674

---

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GSP F 2000

Chain	Residue
F	SER154
F	ALA155
F	LEU156
F	MG2001
E	GLY155
E	HOH3001
F	SER20
F	GLY21
F	VAL22
F	GLY23
F	LYS24
F	SER25
F	ASN26
F	PHE36
F	ASN37
F	LEU38
F	THR43
F	ALA68
F	GLY69
F	ASN124
F	LYS125
F	ASP127
F	LEU128

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 2001

Chain	Residue
F	LYS24
F	SER25
F	THR43
F	ASP66
F	THR67
F	GSP2000

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
B	VAL14-LEU27

---

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKcg.DDLRQEllafQ

Chain	Residue	Details
A	VAL548-GLN562

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycLvcYLLqVkDRHngN

Chain	Residue	Details
A	SER641-ASN661

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	33
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	57
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15837192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---