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4D0L

Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS

Functional Information from GO Data
ChainGOidnamespacecontents
A0016301molecular_functionkinase activity
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000281biological_processmitotic cytokinesis
B0000922cellular_componentspindle pole
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005771cellular_componentmultivesicular body
B0005794cellular_componentGolgi apparatus
B0005802cellular_componenttrans-Golgi network
B0005813cellular_componentcentrosome
B0005814cellular_componentcentriole
B0005828cellular_componentkinetochore microtubule
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006887biological_processexocytosis
B0006904biological_processvesicle docking involved in exocytosis
B0007018biological_processmicrotubule-based movement
B0007080biological_processmitotic metaphase chromosome alignment
B0008017molecular_functionmicrotubule binding
B0010008cellular_componentendosome membrane
B0010634biological_processpositive regulation of epithelial cell migration
B0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0019905molecular_functionsyntaxin binding
B0030133cellular_componenttransport vesicle
B0030659cellular_componentcytoplasmic vesicle membrane
B0030666cellular_componentendocytic vesicle membrane
B0030672cellular_componentsynaptic vesicle membrane
B0030953biological_processastral microtubule organization
B0031175biological_processneuron projection development
B0031410cellular_componentcytoplasmic vesicle
B0031489molecular_functionmyosin V binding
B0031982cellular_componentvesicle
B0032154cellular_componentcleavage furrow
B0032402biological_processmelanosome transport
B0032465biological_processregulation of cytokinesis
B0032588cellular_componenttrans-Golgi network membrane
B0032991cellular_componentprotein-containing complex
B0034394biological_processprotein localization to cell surface
B0036258biological_processmultivesicular body assembly
B0043001biological_processGolgi to plasma membrane protein transport
B0045335cellular_componentphagocytic vesicle
B0045724biological_processpositive regulation of cilium assembly
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048227biological_processplasma membrane to endosome transport
B0051223biological_processregulation of protein transport
B0051650biological_processestablishment of vesicle localization
B0051959molecular_functiondynein light intermediate chain binding
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060627biological_processregulation of vesicle-mediated transport
B0061502biological_processearly endosome to recycling endosome transport
B0061512biological_processprotein localization to cilium
B0070062cellular_componentextracellular exosome
B0071806biological_processprotein transmembrane transport
B0072594biological_processestablishment of protein localization to organelle
B0072659biological_processprotein localization to plasma membrane
B0090150biological_processestablishment of protein localization to membrane
B0090307biological_processmitotic spindle assembly
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098830cellular_componentpresynaptic endosome
B0098837cellular_componentpostsynaptic recycling endosome
B0098876biological_processvesicle-mediated transport to the plasma membrane
B0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
B0098978cellular_componentglutamatergic synapse
B0099003biological_processvesicle-mediated transport in synapse
B0099532biological_processsynaptic vesicle endosomal processing
B0150093biological_processamyloid-beta clearance by transcytosis
B1902017biological_processregulation of cilium assembly
B1902954biological_processregulation of early endosome to recycling endosome transport
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1903438biological_processpositive regulation of mitotic cytokinetic process
B1904779biological_processregulation of protein localization to centrosome
B1905345biological_processprotein localization to cleavage furrow
B1990182biological_processexosomal secretion
B2001135biological_processregulation of endocytic recycling
C0016301molecular_functionkinase activity
C0046854biological_processphosphatidylinositol phosphate biosynthetic process
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000281biological_processmitotic cytokinesis
D0000922cellular_componentspindle pole
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005771cellular_componentmultivesicular body
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005813cellular_componentcentrosome
D0005814cellular_componentcentriole
D0005828cellular_componentkinetochore microtubule
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006887biological_processexocytosis
D0006904biological_processvesicle docking involved in exocytosis
D0007018biological_processmicrotubule-based movement
D0007080biological_processmitotic metaphase chromosome alignment
D0008017molecular_functionmicrotubule binding
D0010008cellular_componentendosome membrane
D0010634biological_processpositive regulation of epithelial cell migration
D0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016192biological_processvesicle-mediated transport
D0016787molecular_functionhydrolase activity
D0019905molecular_functionsyntaxin binding
D0030133cellular_componenttransport vesicle
D0030659cellular_componentcytoplasmic vesicle membrane
D0030666cellular_componentendocytic vesicle membrane
D0030672cellular_componentsynaptic vesicle membrane
D0030953biological_processastral microtubule organization
D0031175biological_processneuron projection development
D0031410cellular_componentcytoplasmic vesicle
D0031489molecular_functionmyosin V binding
D0031982cellular_componentvesicle
D0032154cellular_componentcleavage furrow
D0032402biological_processmelanosome transport
D0032465biological_processregulation of cytokinesis
D0032588cellular_componenttrans-Golgi network membrane
D0032991cellular_componentprotein-containing complex
D0034394biological_processprotein localization to cell surface
D0036258biological_processmultivesicular body assembly
D0043001biological_processGolgi to plasma membrane protein transport
D0045335cellular_componentphagocytic vesicle
D0045724biological_processpositive regulation of cilium assembly
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048227biological_processplasma membrane to endosome transport
D0051223biological_processregulation of protein transport
D0051650biological_processestablishment of vesicle localization
D0051959molecular_functiondynein light intermediate chain binding
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0060627biological_processregulation of vesicle-mediated transport
D0061502biological_processearly endosome to recycling endosome transport
D0061512biological_processprotein localization to cilium
D0070062cellular_componentextracellular exosome
D0071806biological_processprotein transmembrane transport
D0072594biological_processestablishment of protein localization to organelle
D0072659biological_processprotein localization to plasma membrane
D0090150biological_processestablishment of protein localization to membrane
D0090307biological_processmitotic spindle assembly
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098830cellular_componentpresynaptic endosome
D0098837cellular_componentpostsynaptic recycling endosome
D0098876biological_processvesicle-mediated transport to the plasma membrane
D0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
D0098978cellular_componentglutamatergic synapse
D0099003biological_processvesicle-mediated transport in synapse
D0099532biological_processsynaptic vesicle endosomal processing
D0150093biological_processamyloid-beta clearance by transcytosis
D1902017biological_processregulation of cilium assembly
D1902954biological_processregulation of early endosome to recycling endosome transport
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1903438biological_processpositive regulation of mitotic cytokinetic process
D1904779biological_processregulation of protein localization to centrosome
D1905345biological_processprotein localization to cleavage furrow
D1990182biological_processexosomal secretion
D2001135biological_processregulation of endocytic recycling
E0016301molecular_functionkinase activity
E0046854biological_processphosphatidylinositol phosphate biosynthetic process
F0000139cellular_componentGolgi membrane
F0000166molecular_functionnucleotide binding
F0000281biological_processmitotic cytokinesis
F0000922cellular_componentspindle pole
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005771cellular_componentmultivesicular body
F0005794cellular_componentGolgi apparatus
F0005802cellular_componenttrans-Golgi network
F0005813cellular_componentcentrosome
F0005814cellular_componentcentriole
F0005828cellular_componentkinetochore microtubule
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006887biological_processexocytosis
F0006904biological_processvesicle docking involved in exocytosis
F0007018biological_processmicrotubule-based movement
F0007080biological_processmitotic metaphase chromosome alignment
F0008017molecular_functionmicrotubule binding
F0010008cellular_componentendosome membrane
F0010634biological_processpositive regulation of epithelial cell migration
F0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0016192biological_processvesicle-mediated transport
F0016787molecular_functionhydrolase activity
F0019905molecular_functionsyntaxin binding
F0030133cellular_componenttransport vesicle
F0030659cellular_componentcytoplasmic vesicle membrane
F0030666cellular_componentendocytic vesicle membrane
F0030672cellular_componentsynaptic vesicle membrane
F0030953biological_processastral microtubule organization
F0031175biological_processneuron projection development
F0031410cellular_componentcytoplasmic vesicle
F0031489molecular_functionmyosin V binding
F0031982cellular_componentvesicle
F0032154cellular_componentcleavage furrow
F0032402biological_processmelanosome transport
F0032465biological_processregulation of cytokinesis
F0032588cellular_componenttrans-Golgi network membrane
F0032991cellular_componentprotein-containing complex
F0034394biological_processprotein localization to cell surface
F0036258biological_processmultivesicular body assembly
F0043001biological_processGolgi to plasma membrane protein transport
F0045335cellular_componentphagocytic vesicle
F0045724biological_processpositive regulation of cilium assembly
F0048169biological_processregulation of long-term neuronal synaptic plasticity
F0048227biological_processplasma membrane to endosome transport
F0051223biological_processregulation of protein transport
F0051650biological_processestablishment of vesicle localization
F0051959molecular_functiondynein light intermediate chain binding
F0055037cellular_componentrecycling endosome
F0055038cellular_componentrecycling endosome membrane
F0060627biological_processregulation of vesicle-mediated transport
F0061502biological_processearly endosome to recycling endosome transport
F0061512biological_processprotein localization to cilium
F0070062cellular_componentextracellular exosome
F0071806biological_processprotein transmembrane transport
F0072594biological_processestablishment of protein localization to organelle
F0072659biological_processprotein localization to plasma membrane
F0090150biological_processestablishment of protein localization to membrane
F0090307biological_processmitotic spindle assembly
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098830cellular_componentpresynaptic endosome
F0098837cellular_componentpostsynaptic recycling endosome
F0098876biological_processvesicle-mediated transport to the plasma membrane
F0098887biological_processneurotransmitter receptor transport, endosome to postsynaptic membrane
F0098978cellular_componentglutamatergic synapse
F0099003biological_processvesicle-mediated transport in synapse
F0099532biological_processsynaptic vesicle endosomal processing
F0150093biological_processamyloid-beta clearance by transcytosis
F1902017biological_processregulation of cilium assembly
F1902954biological_processregulation of early endosome to recycling endosome transport
F1903078biological_processpositive regulation of protein localization to plasma membrane
F1903438biological_processpositive regulation of mitotic cytokinetic process
F1904779biological_processregulation of protein localization to centrosome
F1905345biological_processprotein localization to cleavage furrow
F1990182biological_processexosomal secretion
F2001135biological_processregulation of endocytic recycling
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 093 A 2002
ChainResidue
ALEU374
AASP674
APRO381
AILE547
ALYS549
ATYR583
APRO597
AVAL598
AALA601
AILE673

site_idAC2
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GSP B 2000
ChainResidue
AGLY155
BSER20
BGLY21
BVAL22
BGLY23
BLYS24
BSER25
BASN26
BPHE36
BASN37
BLEU38
BSER42
BTHR43
BALA68
BGLY69
BASN124
BLYS125
BASP127
BLEU128
BSER154
BALA155
BLEU156
BMG2001
BHOH3001

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 2001
ChainResidue
BSER25
BTHR43
BGSP2000
BHOH3001

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 093 C 2002
ChainResidue
CPRO381
CILE547
CLYS549
CTYR583
CPRO597
CVAL598
CALA601
CLEU663
CILE673
CASP674

site_idAC5
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GSP D 2000
ChainResidue
DSER20
DGLY21
DGLY23
DLYS24
DSER25
DASN26
DPHE36
DASN37
DLEU38
DSER40
DTHR43
DGLY69
DASN124
DLYS125
DASP127
DLEU128
DSER154
DALA155
DLEU156
DMG2001

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 2001
ChainResidue
DSER25
DTHR43
DGSP2000

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 093 E 2002
ChainResidue
EPRO381
EILE547
ELYS549
ETYR583
EPRO597
EVAL598
EALA601
EILE673
EASP674

site_idAC8
Number of Residues23
DetailsBINDING SITE FOR RESIDUE GSP F 2000
ChainResidue
FSER154
FALA155
FLEU156
FMG2001
EGLY155
EHOH3001
FSER20
FGLY21
FVAL22
FGLY23
FLYS24
FSER25
FASN26
FPHE36
FASN37
FLEU38
FTHR43
FALA68
FGLY69
FASN124
FLYS125
FASP127
FLEU128

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG F 2001
ChainResidue
FLYS24
FSER25
FTHR43
FASP66
FTHR67
FGSP2000

Functional Information from PROSITE/UniProt
site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL
ChainResidueDetails
BVAL14-LEU27

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. VKcg.DDLRQEllafQ
ChainResidueDetails
AVAL548-GLN562

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycLvcYLLqVkDRHngN
ChainResidueDetails
ASER641-ASN661

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH
ChainResidueDetails
BSER20
DSER20
FSER20

site_idSWS_FT_FI2
Number of Residues36
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH, ECO:0007744|PDB:2HV8
ChainResidueDetails
BGLY21
BASP127
BALA155
BLEU156
DGLY21
DGLY23
DLYS24
DASN26
DASN37
DLEU38
DSER40
BGLY23
DGLY69
DLYS125
DASP127
DALA155
DLEU156
FGLY21
FGLY23
FLYS24
FASN26
FASN37
BLYS24
FLEU38
FSER40
FGLY69
FLYS125
FASP127
FALA155
FLEU156
BASN26
BASN37
BLEU38
BSER40
BGLY69
BLYS125

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0007744|PDB:2GZH
ChainResidueDetails
BVAL22
DVAL22
FVAL22

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:15837192, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:1OIX, ECO:0007744|PDB:1YZK, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH, ECO:0007744|PDB:2HV8
ChainResidueDetails
BSER25
BTHR43
DSER25
DTHR43
FSER25
FTHR43

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH
ChainResidueDetails
BSER42
DSER42
FSER42

site_idSWS_FT_FI6
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD
ChainResidueDetails
BASP66
DASP66
FASP66

site_idSWS_FT_FI7
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:16905101, ECO:0000269|PubMed:17007872, ECO:0000269|PubMed:17030804, ECO:0007744|PDB:2D7C, ECO:0007744|PDB:2GZD, ECO:0007744|PDB:2GZH
ChainResidueDetails
BASN124
DASN124
FASN124

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: N-acetylglycine => ECO:0000269|Ref.11
ChainResidueDetails
BGLY2
DGLY2
FGLY2

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Cysteine methyl ester => ECO:0000255
ChainResidueDetails
BCYS213
DCYS213
FCYS213

site_idSWS_FT_FI10
Number of Residues6
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:24023390
ChainResidueDetails
BCYS212
BCYS213
DCYS212
DCYS213
FCYS212
FCYS213

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215
ChainResidueDetails
BARG4
DARG4
FARG4

237735

PDB entries from 2025-06-18

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