4CYY
The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002526 | biological_process | acute inflammatory response |
| A | 0002544 | biological_process | chronic inflammatory response |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0015938 | biological_process | coenzyme A catabolic process |
| A | 0015939 | biological_process | pantothenate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016811 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| A | 0017159 | molecular_function | pantetheine hydrolase activity |
| A | 0033089 | biological_process | positive regulation of T cell differentiation in thymus |
| A | 0035577 | cellular_component | azurophil granule membrane |
| A | 0045087 | biological_process | innate immune response |
| A | 0098552 | cellular_component | side of membrane |
| A | 0098609 | biological_process | cell-cell adhesion |
| A | 1902177 | biological_process | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000305|PubMed:25478849 |
| Chain | Residue | Details |
| A | GLU79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000305|PubMed:25478849 |
| Chain | Residue | Details |
| A | LYS178 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000269|PubMed:25478849 |
| Chain | Residue | Details |
| A | CYS211 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: GPI-anchor amidated glycine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY491 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY |
| Chain | Residue | Details |
| A | ASN38 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY |
| Chain | Residue | Details |
| A | ASN130 | |
| A | ASN315 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:4CYY |
| Chain | Residue | Details |
| A | ASN200 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN283 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY |
| Chain | Residue | Details |
| A | ASN353 |
