4CYU
Staphylococcus aureus 7,8-Dihydro-6-hydroxymethylpterin- pyrophosphokinase in complex with AMPCPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| C | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| C | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| D | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| D | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 170 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC1158 |
| A | HOH2002 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 171 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC1158 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 170 |
| Chain | Residue |
| B | VAL96 |
| B | ASP97 |
| B | APC1159 |
| B | HOH2001 |
| B | GLU78 |
| B | ASP95 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 171 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | APC1159 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 170 |
| Chain | Residue |
| C | ASP95 |
| C | ASP97 |
| C | APC1158 |
| C | HOH2001 |
| C | HOH2002 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 171 |
| Chain | Residue |
| C | ASP95 |
| C | ASP97 |
| C | APC1158 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 170 |
| Chain | Residue |
| D | ASP95 |
| D | ASP97 |
| D | APC1158 |
| D | HOH2002 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 171 |
| Chain | Residue |
| D | ASP95 |
| D | ASP97 |
| D | APC1158 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE APC A 1158 |
| Chain | Residue |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | LYS110 |
| A | LEU111 |
| A | SER112 |
| A | HIS115 |
| A | ARG117 |
| A | ARG121 |
| A | MG170 |
| A | MG171 |
| A | HOH2002 |
| A | HOH2005 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE APC B 1159 |
| Chain | Residue |
| A | GLN3 |
| B | ARG92 |
| B | ASP95 |
| B | ASP97 |
| B | ILE98 |
| B | LYS110 |
| B | LEU111 |
| B | SER112 |
| B | MG170 |
| B | MG171 |
| B | HOH2001 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE APC C 1158 |
| Chain | Residue |
| C | LEU71 |
| C | ARG92 |
| C | ASP95 |
| C | ASP97 |
| C | ILE98 |
| C | LYS110 |
| C | LEU111 |
| C | SER112 |
| C | HIS115 |
| C | ARG117 |
| C | ARG121 |
| C | MG170 |
| C | MG171 |
| C | HOH2002 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE APC D 1158 |
| Chain | Residue |
| C | GLN3 |
| D | LEU71 |
| D | ARG92 |
| D | ASP95 |
| D | ASP97 |
| D | ILE98 |
| D | LYS110 |
| D | LEU111 |
| D | SER112 |
| D | MG170 |
| D | MG171 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRS B 1160 |
| Chain | Residue |
| B | ASN27 |
| B | GLU28 |
| B | TYR29 |
| B | ASP30 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRS A 1159 |
| Chain | Residue |
| A | ASN27 |
| A | GLU28 |
| A | TYR29 |
| A | ASP30 |
| A | ILE32 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL |
| Chain | Residue | Details |
| A | ARG88-LEU99 | |
| B | ARG88-LEU99 |
