4CTS
CRYSTAL STRUCTURE ANALYSIS AND MOLECULAR MODEL OF A COMPLEX OF CITRATE SYNTHASE WITH OXALOACETATE AND S-ACETONYL-COENZYME A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004108 | molecular_function | citrate (Si)-synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006101 | biological_process | citrate metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0036440 | molecular_function | citrate synthase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0004108 | molecular_function | citrate (Si)-synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006101 | biological_process | citrate metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0036440 | molecular_function | citrate synthase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OAA A 438 |
| Chain | Residue |
| A | HIS238 |
| A | ASN242 |
| A | HIS274 |
| A | HIS320 |
| A | ALA321 |
| A | ARG329 |
| A | ARG401 |
| B | ARG421 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OAA B 438 |
| Chain | Residue |
| B | HIS238 |
| B | ASN242 |
| B | HIS274 |
| B | HIS320 |
| B | ARG329 |
| B | ARG401 |
| A | ARG421 |
Functional Information from PROSITE/UniProt
| site_id | PS00480 |
| Number of Residues | 13 |
| Details | CITRATE_SYNTHASE Citrate synthase signature. GYGHaVl.RktDPR |
| Chain | Residue | Details |
| A | GLY317-ARG329 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | HIS274 | |
| A | HIS320 | |
| A | ASP375 | |
| B | HIS274 | |
| B | HIS320 | |
| B | ASP375 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q29RK1 |
| Chain | Residue | Details |
| A | LYS49 | |
| B | LYS49 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9CZU6 |
| Chain | Residue | Details |
| A | LYS76 | |
| A | LYS166 | |
| A | LYS423 | |
| B | LYS76 | |
| B | LYS166 | |
| B | LYS423 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9CZU6 |
| Chain | Residue | Details |
| A | SER199 | |
| B | SER199 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CZU6 |
| Chain | Residue | Details |
| A | LYS294 | |
| B | LYS432 | |
| A | LYS300 | |
| A | LYS348 | |
| A | LYS366 | |
| A | LYS432 | |
| B | LYS294 | |
| B | LYS300 | |
| B | LYS348 | |
| B | LYS366 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O75390 |
| Chain | Residue | Details |
| A | LYS355 | |
| B | LYS355 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:7093227 |
| Chain | Residue | Details |
| A | LYS368 | |
| B | LYS368 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | ASP375 | |
| A | HIS274 | |
| A | HIS320 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | ASP375 | |
| B | HIS274 | |
| B | HIS320 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| A | ASP375 | |
| A | HIS320 | |
| A | HIS274 | |
| A | SER244 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1aj8 |
| Chain | Residue | Details |
| B | ASP375 | |
| B | HIS320 | |
| B | HIS274 | |
| B | SER244 |
