4CTK

DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	methyltransferase cap1 activity
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
C	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
C	0004483	molecular_function	methyltransferase cap1 activity
C	0008168	molecular_function	methyltransferase activity
C	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAM A 1263

Chain	Residue
A	SER56
A	HIS110
A	GLU111
A	LYS130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	HOH2166
A	HOH2170
A	HOH2198
A	GLY58
A	HOH2368
A	GLY81
A	CYS82
A	GLY83
A	GLY86
A	TRP87
A	THR104
A	LYS105

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAM C 1263

Chain	Residue
C	SER56
C	GLY58
C	GLY81
C	CYS82
C	GLY83
C	GLY86
C	TRP87
C	THR104
C	LYS105
C	HIS110
C	LYS130
C	ASP131
C	VAL132
C	PHE133
C	ASP146
C	ILE147
C	HOH2130
C	HOH2134
C	HOH2157
C	HOH2288

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SVN A 1264

Chain	Residue
A	LEU17
A	LEU20
A	SER21
A	PHE25
A	SVN1266
A	HOH2041

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 1265

Chain	Residue
A	GLY109

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SVN A 1266

Chain	Residue
A	ASN18
A	GLU67
A	ASN69
A	PRO152
A	SVN1264

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 1267

Chain	Residue
A	TYR28
A	ARG241
A	PHE242
A	MET244
A	HOH2054

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Interaction with host SCRIB","evidences":[{"source":"UniProtKB","id":"Q01299","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Motif: {"description":"SUMO-interacting motif","evidences":[{"source":"UniProtKB","id":"P29990","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---